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Abstract Details

Direct Clinical Applications of Natural Language Processing in Common Neurological Disorders: A Systematic Review
General Neurology
P5 - Poster Session 5 (11:45 AM-12:45 PM)
12-005
We sought to evaluate studies that applied natural language processing (NLP) to the diagnosis, prediction, or treatment of common neurological disorders.
NLP, a branch of artificial intelligence that analyzes unstructured language, is being increasingly utilized in medicine. However, the extent to which NLP has been studied in neurological disorders remains inconsistently characterized.
This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards and was registered with the Prospective Register of Systematic Reviews (PROSPERO; CRD42021228703). The search was conducted using MEDLINE and EMBASE on May 11, 2022. We included studies of NLP use in migraine, Parkinson disease, Alzheimer dementia, stroke and transient ischemic attack (TIA), epilepsy, or multiple sclerosis. We excluded non-English language, conference abstract, and review articles, as well as studies involving heterogeneous clinical populations or indirect clinical uses of NLP. Study characteristics were extracted and analyzed using descriptive statistics.
We identified 916 studies, of which 41 (4.5%), published between 2013 and 2022, were included in the final review. The most studied disorders were stroke and TIA (N=20 studies, 48.8%), followed by epilepsy (N=10, 24.4%), Alzheimer disease (N=6, 14.6%), and multiple sclerosis (N=5, 12.2%). We found no studies of NLP use in migraine or Parkinson disease that met our eligibility criteria. The main objective of NLP was diagnosis (N=20, 48.8%) followed by disease phenotyping (N=17, 41.5%), prognostication (N=9, 22%) and treatment (N=4, 9.8%). Eighteen (43.9%) studies used only machine learning approaches, 6 (14.6%) used only rule-based methods, and 17 (41.5%) used both. 
We found several gaps in neurological NLP research, with few to no studies in certain disorders, suggesting additional areas of inquiry. We observed that NLP was most widely studied in diagnostic applications, implying a potential role for NLP in augmenting diagnostic accuracy in settings with limited access to neurological expertise.
Authors/Disclosures
Ilana Lefkovitz, MD (Mount Sinai Beth Israel)
PRESENTER 		Dr. Lefkovitz has nothing to disclose.
No disclosure on file
Leah Blank, MD (Icahn School of Medicine at Mount Sinai) The institution of an immediate family member of Dr. Blank has received personal compensation in the range of $0-$499 for serving as a Consultant for Bristol Myers Squibb (Legal). The institution of Dr. Blank has received research support from NIH. Dr. Blank has received personal compensation in the range of $500-$4,999 for serving as a Mentee, Reimbursement for travel/research with University of Calgary.
Nathalie Jette, MD, MSc, FRCPC, FAAN (University of Calgary) Dr. Jette has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for ILAE Epilepsia. The institution of Dr. Jette has received research support from NIH. The institution of Dr. Jette has received research support from AES.
Benjamin R. Kummer, MD, FAAN Dr. Kummer has received personal compensation in the range of $0-$499 for serving as a Consultant for AlphaSights. Dr. Kummer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Syapse. Dr. Kummer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for NeuraHealth. Dr. Kummer has received personal compensation in the range of $0-$499 for serving as a Consultant for RONIN. Dr. Kummer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint Global. Dr. Kummer has received personal compensation in the range of $0-$499 for serving as a Consultant for GLG. Dr. Kummer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Petauri Kinect. Dr. Kummer has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for 好色先生 . Dr. Kummer has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JMIR. Dr. Kummer has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Seminars in Neurology. Dr. Kummer has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Yoeli Gottlieb Etra LLP. Dr. Kummer has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for The Ashley Law Firm. Dr. Kummer has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Burns White Attorneys at Law. Dr. Kummer has stock in Syntrillo. The institution of Dr. Kummer has received research support from Icahn School of Medicine at Mount Sinai. Dr. Kummer has a non-compensated relationship as a Vice Chair Telehealth Subcommitte with 好色先生 that is relevant to AAN interests or activities. Dr. Kummer has a non-compensated relationship as a Vice Chair Quality Informatics Subcommittee with 好色先生 that is relevant to AAN interests or activities.