To evaluate differences in characteristics and outcomes among males and females with Todd’s paralysis in the United States.

Population-level data in the US for patients with Todd’s paralysis is sparse.

Patients with Todd’s paralysis were extracted from the 2019 National Inpatient Sample from HCUP, AHRQ, and partners using the ICD-10 code 'G8384'. Various characteristics were compared between males and females. Multivariable regression analysis allowed us to estimate the mortality risk.

We found 11,175 cases of Todd’s paralysis, amongst which 50.3% were females and 49.7% were males. Both females and males were more likely to be white (61.5% and 60.3%, p<0.01) and covered by Medicare (60.4% and 51.4%, p<0.01). Males were more likely to have alcohol abuse (13.7% vs. 6.9%, p<0.01), drug abuse (7.7% vs. 4.4%, p<0.01), be a smoker (42.4% vs. 30.4%, p<0.01), have cirrhosis (4.8% vs. 2.5%, p<0.01), involve cannabis use (5.4% vs. 2.0, p<0.01) than females. Meanwhile, females showed a higher incidence of depression (18.7% vs. 13.1%, p<0.01), Chronic Pulmonary Disease (19.2% vs. 16.0%, p<0.01), obesity (61.6%vs. 38.4, p<0.01), and hypertension (68.5% vs. 65.8%, p<0.01) than males. Females were also older than males (mean age 61.67 years vs. 57.54 years) and had a longer stay (6.52 days vs. 6.22 days) but a lower mean hospital charge of $77504.98 vs. $79503.05. After adjusting for multiple variables, females also showed a lower adjusted odds ratio of death (aOR 0.687, 95% CI 0.485-0.973, p=0.034).

Females with Todd’s paralysis have a lower risk of death than males. Several differences exist in patient characteristics.