Abstract Details

Title Age-related Macular Degeneration, Incident Ischemic Stroke, and Cognitive impairment

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P14 - Poster Session 14 (11:45 AM-12:45 PM)

Poster/Presentation
Number 6-024

Objective To assess the risk of incident stroke and cognitive impairment in subjects with and without AMD.

Background Retinal-vascular disorders have been associated with adverse cardiovascular outcomes but the association between age-related macular degeneration (AMD), a common degenerative disorder of the retina and choroid, and incident stroke and cognitive impairment has not been well established.

Design/Methods We conducted a case-control, longitudinal study of subjects aged ≥40 years with retinal optical coherence tomography (OCT) imaging and brain MRI scanning from 2011–2015. Each subject with AMD was age-matched to a control subject without AMD in a 1:1 ratio and followed longitudinally for incident stroke and cognitive impairment until September 2021. AMD was diagnosed according to retinal abnormalities on OCT, ischemic stroke was diagnosed by a physician according to radiographic evidence of infarction, and cognitive impairment was diagnosed according to a Montreal Cognitive Assessment score of ≤19 or a Kokmen short test score of ≤29. Cox regression models evaluated the relationships between AMD and incident stroke and cognitive impairment.

Results Of the 256 age-matched pairs included in our study (AMD: 126; no AMD: 130), the mean age was 75±9 years, 60.2% were women, and there were no differences in age or vascular risk factors between groups. During a median follow-up of 7.4 years, 26 subjects had incident strokes, and 34 developed cognitive impairment. After adjusting for vascular risk factors, AMD trended to associate with incident stroke (aHR 1.75, 95% CI 0.79-3.91, p=0.170) and cognitive impairment (aHR 1.93, 95% CI 0.93-4.01, p=0.077).

Conclusions In our study, while there was not statistically significant association of AMD with either incident stroke or cognitive impairment, the direction of effect was suggestive of increased risk for both. Future studies are needed to further explore possible relationships between AMD, stroke and neurodegeneration.

Authors/Disclosures
Bhrugun Anisetti, MBBS PRESENTER	Dr. Anisetti has nothing to disclose.
	No disclosure on file
Eric R. Eggenberger, DO, FAAN (Mayo Clinic Florida)	Dr. Eggenberger has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Welch-Allyn. Dr. Eggenberger has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Illinois Institute of Technology (IITT). Dr. Eggenberger has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx.
Nilufer Taner, MD, PhD, FAAN (Mayo Clinic)	The institution of Dr. Taner has received research support from NIH.
James F. Meschia, MD, FAAN (Mayo Clinic)	The institution of Dr. Meschia has received research support from NINDS. The institution of Dr. Meschia has received research support from NINDS.
Michelle P. Lin, CRC (Mayo Clinic Florida)	Dr. Lin has nothing to disclose.

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