Abstract Details

Title Thyroid hormone decreasing after mechanical thrombectomy for cerebral infarction

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 6-018

Objective The aim of this study wasto clarify the changes in thyroid hormone levels in the acute phase and the effects of the iodine contrast agent on thesehormones.

Background Mechanical thrombectomy (MT) is an established treatment for large vessel occlusion in patients with cerebral infarction. The use of iodine contrast agent decreases thyroid hormone levels via the so-called Wolff-Chaikoff effect. Low triiodothyronine (T3) syndrome caused by a severe illness status can contribute to decreased thyroid hormones. Reportedly, a low T3 level is associated with poor prognosis in patients with cerebral infarction.

Design/Methods This was a single-center, prospective, and single-arm trial. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were tested on admission and 24 h postoperatively in patients who were approved for MT.

Results A total of 37 patients were screened during the study period and 31 patients were enrolled. Significant decreases were observed in TSH (P < 0.001) and FT3 (P < 0.001) levels 24 h after MT. Moreover, there was a correlation between the decrease ratio of change in FT3 levels and the amount of iodine contrast agent used per body surface area (r = 0.43, P = 0.019), while no such correlations were detected for TSH and FT4.

Conclusions We demonstrated that decrease in TSH and FT3 levels in the acute phase after MT and that FT3 levels were associated with the amount of iodine contrast agent used.

Authors/Disclosures
Yuya Kobayashi (Ina Central Hospital) PRESENTER	Dr. Kobayashi has nothing to disclose.

��ɫ��

��ɫ��