Consecutive ischemic stroke patients treated with thrombolysis or endovascular thrombectomy were used in this analysis. DAOH-90 was calculated from the national minimum dataset, an administrative nationwide database. mRS was assessed with in-person or telephone interviews. Simple descriptive statistics were applied (median [IQR]). The ability of DAOH-90 to distinguish between the commonly applied cut-points of mRS-90 was assessed using the area under the receiver operating curve (AUROC). Prognostic variables previously validated for mRS were assessed with Spearman’s correlation.

1278 ischemic stroke patients (714 male, median age 70[59-79], median NIHSS 14[9-20] were included in this study. Overall, median DAOH-90 was 71[29-84] and median mRS-90 was 3 [2-5]. There was a strong association between mRS-90 and DAOH-90 (spearman rho correlation 0.79, p<0.001). AUROC (95% CI) for predicting mRS > 0, mRS >1, mRS>2 were 0.86 (0.84-0.88), AUC 0.88 (0.86-0.90), AUC 0.90 (0.89-0.92) respectively. DAOH-90 was significantly correlated with age (spearman rho -0.13, p<0.001), admission NIHSS (spearman -0.44, p<0.001), Alberta stroke programme early CT score (spearman rho 0.24, p<0.001), and admission blood glucose concentration (spearman -0.24, p<0.001).