Abstract Details

Title Lack of Pre-treatment Thrombolysis and Low ASPECTS are Associated with Poor Rates of Recanalization After Mechanical Thrombectomy

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P8 - Poster Session 8 (11:45 AM-12:45 PM)

Poster/Presentation
Number 6-025

Objective

To identify factors associated with poor rates of recanalization in patients with large vessel occlusion ischemic stroke undergoing mechanical thrombectomy.

Background Mechanical thrombectomy (MT) has been effective in treating ischemic strokes due to large vessel occlusion (LVO). However, all patients with LVO who are deemed candidates for MT do not have successful rates of recanalization and a favorable outcome. Hence, we studied factors associated with an unfavorable outcome in patients undergoing MT.

Design/Methods We retrospectively analyzed forty patients with LVO ischemic stroke undergoing MT. We included patients with anterior circulation LVO strokes who were deemed candidates for MT. Patient underwent CTA imaging upon arrival in the emergency room. We collected important variables including initial NIHSS, pre-morbid modified Rankin Scale (mRS), administration of thrombolysis, location of LVO, ASPECTS, TICI (thrombolysis in cerebral infarction) score. Functional outcome was measured with NIHSS and mRS at discharge.

Results 40 patients with LVO who underwent MT (age 68 ±15); 62.4 % female; NIHSS 16). Patients were divided into four groups based on TICI scores into those with 0/1, 2b, 2c and 3. Variables including initial NIHSS, pre-morbid mRS, administration of thrombolysis, location of LVO, ASPECTS and TICI score were compared between these groups. In the TICI 0/1 group, patients had low ASPECTS on arrival and were not treated with thrombolysis prior to thrombectomy. They also had a higher NIHSS and mRS at discharge.

Conclusions

Lack of pre-treatment thrombolysis and low ASPECTS on presentation were associated with poor rates of recanalization after mechanical thrombectomy.

Authors/Disclosures
Muhammad M. Alvi, MD, FAAN (West Virginia University) PRESENTER	Dr. Alvi has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Brainomix.
Krithika Umesh Peshwe, MD (West Virginia University School of Medicine)	Dr. Peshwe has nothing to disclose.

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