A 71-year-old healthy female presented with 2-months of recurrent falls and intermittent jerking of left arm and leg that started 5 days after her COVID-19 vaccine booster. At baseline she lives by herself and can manage her 10-acre property. On exam, she has appropriate mood, intact cognition, and orientation. Speech was dysarthric and was rigid in all muscle groups associated with hyperreflexia. The intermittent left hemibody jerking was consistent with focal myoclonus associated with spike and wave discharges on EEG. Brain magnetic resonance imaging (MRI) showed increased signal in the bilateral caudate, putamen, medial thalami, and right cerebral cortex on diffusion-weighted imaging. Cerebrospinal fluid (CSF) analysis showed normal cell count, protein and negative for autoimmune/paraneoplastic antibodies. While in the hospital over a few weeks her symptoms progressed to akinetic mutism, and she developed cognitive dysfunction. Real-time Quaking Induced Conversion (RT-QuIC), T-tau protein, and 14-3-3 protein ultimately resulted positive on CSF confirming diagnosis of CJD. She was discharged home with palliative care.