302 e-consults were reviewed. The median time from e-consult order to completion was 3 days. The median age was 53 years and 68.5% were female. Most referring providers were attending physicians (51.3%), followed by advanced practice providers (34.1%) and resident trainees (14.6%). The most frequent referrals were for headache (n=125, 41.4%), dysesthesia (n=40, 13.2%), and abnormal imaging finding (n=27, 8.9%). The most common e-consult questions were for treatment (57.6%) and diagnostic evaluation (48.0%) recommendations. 24.8% of e-consults were followed by FTF-consults. Primary risk factors associated with subsequent FTF-consult included female sex (HR=1.9), referral for headache (HR=1.7), and final diagnosis of migraine (HR=2.0) or chronic migraine (HR 5.0). Potential harm related to delayed diagnosis/treatment was identified in 6 (2.0%) patients with migraine and 4 (1.3%) without migraine presenting to emergency department.