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Abstract Details

Motor Nerve Conduction Slowing in Amyotrophic Lateral Sclerosis
Neuromuscular and Clinical Neurophysiology (EMG)
P10 - Poster Session 10 (8:00 AM-9:00 AM)
10-006

To determine the range of conduction values for motor nerve conduction slowing and further characterize the distribution of conduction slowing in ALS and characterize the limits of conduction slowing beyond which the diagnosis of ALS is uncertain.
Abnormal motor nerve conduction studies in ALS are attributed to loss of large axons and distal axonopathy, however conduction slowing can be the result of superimposed demyelinating polyneuropathy or an alternate diagnosis.
The electrodiagnostic data of 76 chronic inflammatory demyelinating polyneuropathy (CIDP) patients, identified using AAN research criteria was used to create 12 novel equations using regression analysis that determine a range of the expected slowing of a primary demyelinating polyneuropathy. Demyelinating range confidence intervals were defined by assessing conduction velocity (CV), distal latency (DL), and F latency in relation to distal compound muscle action potential (CMAP) amplitude of median, ulnar, fibular, and tibial nerves. Results were then validated in 38 additional CIDP patients. These developed equations were then used to evaluate conduction slowing in 95 patients with ALS. Transformed CMAP amplitude was used as an independent variable whereas transformed DL, CV, and F were used as dependent variables.
CV slowing, prolonged DL, and abnormal F latency were observed respectively in 22.2%, 19.6%, and 46.7% of the studied nerves. When slowing occurred, it affected more than one segment of the motor nerve, suggesting that loss of large axons is the main mechanism of slowing. No ALS patient had more than 2 nerves with CV slowing in the confidence interval defined by the regression equations or the 好色先生 (AAN) research criteria for CIDP diagnosis.
The presence of more than two motor nerves with CV slowing in the demyelinating range defined by the regression analysis or AAN criteria in ALS patients suggests an alternative diagnosis or superimposed demyelination.
Authors/Disclosures
Kranthi K. Mandava
PRESENTER 		Mr. Mandava has nothing to disclose.
Anam K. Shaikh (New Jersey Medical School) Miss Shaikh has nothing to disclose.
Mustafa Jaffry Mr. Jaffry has nothing to disclose.
Kazim Jaffry Mr. Jaffry has nothing to disclose.
Muhammed Ors Mr. Ors has nothing to disclose.
Ronak U. Trivedi Mr. Trivedi has nothing to disclose.
No disclosure on file
No disclosure on file
Tejas Patel No disclosure on file
Abu Nasar No disclosure on file
Ankit Pahwa Ankit Pahwa has nothing to disclose.
Howard W. Sander, MD, FAAN Dr. Sander has received personal compensation for serving as an employee of Grifols. Dr. Sander has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Law firm.
Nizar Souayah, MD, FAAN (NJMS) Dr. Souayah has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Takeda. Dr. Souayah has received publishing royalties from a publication relating to health care.