Abstract Details

Title Predictors of Mechanical Ventilation Among 1960 Obese Patients Admitted With Guillain-Barré syndrome in the United States

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P12 - Poster Session 12 (5:30 PM-6:30 PM)

Poster/Presentation
Number 10-015

Objective To understand the impact of obesity on the need for mechanical ventilation following admission for Guillain-Barré syndrome (GBS) and the associated risk of mortality.

Background Obesity is a fast-growing risk factor predisposing to many complications. Its impact on the outcomes of GBS patients has not been properly reported in the literature.

Design/Methods Obese patients with a principal diagnosis of GBS were pooled from the 2019 National Inpatient Sample. Logistic regression models, adjusting for confounders, were used to identify potential risk factors for requiring mechanical ventilation and overall mortality risk.

Results A total of 1960 obese patients with GBS were admitted in 2019, and 240 (12.2%) required mechanical ventilation. Arthropathies (aOR 4.876, 95% CI 2.582-9.206, p<0.01), chronic pulmonary disease (aOR 2.223, 95% CI 1.505- 3.283, p<0.01), acute kidney injury (aOR 6.068, 95% CI 4.047-9.097, p<0.01), ventricular tachycardia (aOR 3.401, 95% CI 1.353-8.549, p<0.01), and paroxysmal atrial fibrillation (aOR 8.176, 95% CI 4.608-14.505, p<0.01) were potential risk factors for requiring mechanical ventilation. Meanwhile hypothyroidism (aoR 0.370, 95% CI 0.216-0.634, p<0.01), diabetes (aOR 0.611, 95% CI 0.398-0.936, p=0.024), and patients covered by Medicaid (aOR 0.351, 95% CI 0.184-0.669, p<0.01), or private insurances (aOR 0.557, 0.351-0.883, p=0.013) (compared to Medicare) were at lower risk. Obese GBS patients using mechanical ventilation also had a higher risk of death (10.4% vs. 0.9%, aOR 47.586, 95% CI 12.334-169.823, p<0.01).

Conclusions Several factors influence the risk of requiring mechanical ventilation among obese GBS patients. Obese patients using mechanical ventilation were at risk of poorer outcomes.

Authors/Disclosures
Sailaja Sanikommu, MBBS (V.N.M Hopsital) PRESENTER	Dr. Sanikommu has nothing to disclose.
Shaheen Sombans, MBBS (Fernandez Foundation)	Dr. Sombans has nothing to disclose.
Kamleshun Ramphul	Kamleshun Ramphul has nothing to disclose.
Renuka Verma (KIRK KERKORIAN SCHOOL OF MEDICINE)	Renuka Verma has nothing to disclose.
	No disclosure on file
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