Abstract Details

Title Orbital Myositis Presenting as a Late Immune-Related Adverse Event Four Months After Stopping Immune Checkpoint Inhibitor

Topic Neuro-ophthalmology/Neuro-otology

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 4-001

Objective NA

Background Immune checkpoint inhibitors (ICIs) are novel immune cancer therapies that have been associated with immune-related adverse events (irAEs) which can involve different organs. Orbital irAEs have been reported, and include orbital myositis, thyroid-like eye disease, Tolosa-Hunt syndrome, and orbital apex syndrome. IrAEs usually present during the ICI therapy course, or within days or weeks after the last dose of ICIs. We are reporting a case of orbital myositis with symptoms onset four months after stopping Pembrolizumab.

Design/Methods NA

Results A 50-year-old woman, who received seven doses of Pembrolizumab for triple-negative breast cancer, presented with acute onset stabbing periorbital pain on the left side and diplopia four months after stopping Pembrolizumab. Neurological examination revealed mild left abduction deficit without ptosis. Initial CT orbits and MRI brain demonstrated enhancing soft tissue mass within the belly of the left lateral rectus muscle. Thyroid function tests were normal and antithyroid antibodies were negative. IgG-4 was marginally elevated (183 mg/dL, normal<123mg/dl). The left lateral rectus muscle biopsy revealed chronic inflammation with mild-to-moderate mixed lymphohistiocytic and plasmocytic infiltrate predominately within the perivascular area with lesser endomysial distribution, but there was no evidence for the IgG4 disease. She didn’t response to oral steroids. The IVIG was aborted due to urticaria after the first dose. Eventually, pulse intravenous methylprednisolone (1g daily for three days) was given, and the symptoms resolved quickly. Mycophenolate mofetil 1gram twice daily was started to prevent relapse. The patient remained stable after five months.

Conclusions Orbital myositis is a rare form of irAE from ICIs, and it can present several months later after ICIs are discontinued.

Authors/Disclosures
Mohammad Dibs, MD (Stormont Vail Health) PRESENTER	Dr. Dibs has nothing to disclose.
Ventaka Bendi, MBBS	Dr. Bendi has nothing to disclose.
	No disclosure on file
	No disclosure on file
Yu-Ting Chen, MD (Immanuel Neurological Institute)	Dr. Chen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam.

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