A multidisciplinary team (resident leaders, program director, clinic manager, nurses, medical assistants, and social workers) developed the depression S&I protocol. Patient Health Questionnaire-9 Adolescent (PHQ-9A) was administered to patients age 12 to 18 years, who were developmentally capable and agreed to complete the screening. Patients received individualized interventions based on our algorithm. Serial Plan-Do-Study-Act (PDSA) cycles were performed, over nine months, to improve efficacy and workflow. PDSA cycle 1 included protocol initiation and education of residents and clinic staff. PDSA cycle 2 included further promotion and addition of dotphrases in the electronic medical record (EMR) documentation. PDSA cycle 3 consisted of re-education and provision of reminder cards at workstations. Measures included percent of eligible patients screened and percent of screened patients who received appropriate interventions.