The electronic medical records of 356 patients seen at our institution between 2018 and 2022 with confirmed POTS diagnoses via tilt table testing were extrapolated. Patients were sub-grouped based upon the presence or absence of a documented psychiatric disorder. The number of treatment course failures, defined as a change or discontinuation of a treatment regimen, after an initial visit with an institutional POTS specialist was collected. Preliminary results were obtained using data from 113 of 356 total patients, as this study is ongoing. Negative binomial regression was used to examine whether the presence of a psychiatric condition was associated with the number of POTS treatment course failures utilizing observation time as the offset term.

If this association remains after analysis of our entire patient cohort, anticipated by 3/1/2023, we suspect this patient population may (1) need increased counseling to recognize the impact of psychiatric disease on POTS therapy and (2) should be encouraged to seek treatment for these comorbidities.