Abstract Details

Title Intracranial Aneurysm In a Case of Tubercular Meningoencephalitis, a Rare Presentation

Topic Infectious Disease

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 13-001

Objective NA

Background In this era of advanced medical science and technology, tuberculosis remains as a major health problem in developing countries like India. While pulmonary TB is the most common manifestation of TB, incidence of extrapulmonary TB is also gradually increasing. Affliction of central nervous system is considered one of the most severe forms of extrapulmonary tuberculosis. Central nervous system (CNS) tuberculosis(TB) comprises 15%–20% of the total cases of extra-pulmonary TB and it is associated with a high mortality rate. Surprisingly a little less than 5% of patients with pulmonary TB develop CNS TB and not all patients with CNS TB have pulmonary TB.
Although CNS involvement by tuberculosis is seen in all age groups, there is a predilection for younger and immunocompromised patients. Central nervous system tuberculosis may present as tubercular meningitis, meningoencephalitis , tuberculoma, tubercular abscess. Vasculitis , secondary to TBM can cause infarcts commonly but development of an intracranial tuberculous aneurysm is a rare complication.

Design/Methods NA

Results

Case Report:

A 33-year-old male presented with a low grade fever, meningism for weeks, diagnosed to have tubercular meningoencephalitis after supportive brain imaging and CSF assay. During course of hospitalization developed left ptosis, binocular horizontal diplopia, dimness of vision of left eye with diminished left periorbital sensation suggestive of a left anterior cavernous sinus syndrome. Brain imaging with angiogram of cerebral vasculature revealed an aneurysm at left ICA-MCA junction, probably a sequalae of granulomatous vasculitis

Conclusions

Discussion:

This case report shows an unusual case of intracranial tuberculomas complicated by intralesional haemorrhage due to an infective tubercular aneurysm. During disease course, MTB may colonize the arterial wall and erode its entire thickness with caseating necrosis, forming an aneurysm. These aneurysms are prone to rupture with fatal complications. Early identification of the disease with proper treatment is critical for the prevention of fatal complications.

Authors/Disclosures
Kuntal Biswas, MD (BANGUR INSTITUTE OF NEUROSCIENCES) PRESENTER	Dr. Biswas has nothing to disclose.
	No disclosure on file
	No disclosure on file
Bhaswar Bhattacharya, Jr. (Bangur Institute of Neurosciences (Annex of IPGMER and SSKM Hospital, Kolkata))	Dr. Bhattacharya has nothing to disclose.
Atanu Biswas, MD (Bangur Institute of Neurosciences)	Dr. Biswas has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for INTAS Pharmaceuticals. Dr. Biswas has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for lupin Limited. Dr. Biswas has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Alkem Laboratories. Dr. Biswas has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Torrent Pharmaceuticals.
Uddalak Chakraborty, MD, MBBS (Bangur Institute of Neurosciences, IPGMER & SSKM Hospital Annex 1)	Dr. Chakraborty has nothing to disclose.

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