Abstract Details

Title Men with dementia are at increased risk of all-cause mortality following SARS-CoV-2 Vaccination

Topic Infectious Disease

Presentation(s) P5 - Poster Session 5 (11:45 AM-12:45 PM)

Poster/Presentation
Number 13-006

Objective This study aimed to figure out the risk factors of all-cause mortality post SARS-CoV-2 vaccination.

Background Amassing reports of death with close temporal association to SARS-CoV-2 vaccination warrants further investigation, especially after a nationwide mass vaccination campaign. With the release of uncontrolled data, vaccine fear and hesitancy fueled by the media prevents effective future implementation of vaccine rollout. As little information is known on this topic, we performed a prospective surveillance study on the risk factors of all-cause mortality post SARS-CoV-2 vaccination.

Design/Methods Of 38,828,692 SARS-CoV-2 vaccine doses administered from February 2021 to March 2022 in the Gyeonggi Province, South Korea, a total of 687 cases of severe serious events and 353 cases of deaths were reported post SARS-CoV-2 vaccination. We compared the demographic characteristics between patients who were deceased, and patients who were reported to have suffered severe serious events but survived. Additionally, survival analysis was performed to assess the contributing risk for post-vaccination mortality.

Results Patients who died following SARS-CoV-2 vaccination were older, hospitalized, vaccinated in nursing facilities, received 3^rddose of vaccine, and had ischemic heart disease or dementia as comorbidity. In multivariate analysis, only male sex (crude IRR, 1.413; 95% CI, 1.026–1.947). and dementia (crude IRR, 1.644; 95% CI, 1.091–2.478) was associated with increased risk of death following vaccination, whereas hospitalization (crude IRR, 0.103; 95% CI, 0.076–0.139) was still significantly associated with decreased risk of mortality.

Conclusions Men with dementia may be at increased risk of death following SARS-CoV-2 vaccination. If severe serious adverse event is suspected, prompt hospitalization may help reduce mortality. Government authorities should pay closer attention to these groups of patients to ensure safety following mass vaccination campaign.

Authors/Disclosures
Jin Myoung Seok, MD (Soonchunhyang University Hospital Cheonan) PRESENTER	Jin Myoung Seok has nothing to disclose.
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