Abstract Details

Title Symptom severity, impairment and health outcomes in patients with Functional Tic Like Behaviours

Topic Movement Disorders

Presentation(s) P11 - Poster Session 11 (11:45 AM-12:45 PM)

Poster/Presentation
Number 5-011

Objective To quantitatively understand symptom severity, impairment, and health outcomes of patients with functional tic-like behaviours (FTLB) compared to Tourette Syndrome (TS) and healthy controls (HC).

Background Functional tic-like behaviors (FTLB) are a previously rare form of functional movement disorder that rose in incidence during the COVID-19 pandemic. Patients report significant disruptions in daily functioning.

Design/Methods As part of a larger data set, patients aged 11-25 years with FTLB (n= 34) were age and sex-matched to TS (n= 21), and healthy controls (HC) (n=21). Groups completed online self-report measures and a clinical neuropsychiatric interview that investigated quality of life, disability, loneliness, suicidality, depression, anxiety, social interaction anxiety, social phobia, current and peak tic-severity, and family functioning. Two-tailed group differences were Bonferroni corrected.

Results Compared to HC and TS, FTLB patients endure higher levels of total disability (p=.037), self-care disability (p=.019), disability related to participation in life activities such as school and work (p=.013), depression (p=.011), and suicidality (p<.001). 61.8% of FTLB patients reported school absence that ranged up to 65% of the time (Mean=20.88%, SD=22.25). FTLB had higher current phonic tic severity (p=.048), and peak motor and phonic tic severity (p<.001; p<.001) than TS. FTLB experience lower quality of life in the physical, psychological, and environmental domains (p=.015; p=.031; p=.042) and significantly higher social interaction anxiety (p=.004), social phobia (p<.001), and loneliness (p=.038) compared to HC. TS and FTLB reported similar levels of tic related impairment, anxiety, and social anxiety/phobia. Family functioning was not significantly different between groups.

Conclusions

FTLB are a highly disabling disorder that severely impacts quality of life, social and adaptive functioning, and mental health. Comparable levels of social anxiety, loneliness, and tic related impairment in TS and FTLB may be due to social apprehension in response to common negative reactions to tics and tic-like behaviors.

Authors/Disclosures
Lindsay Berg, Other PRESENTER	Ms. Berg has nothing to disclose.
Tamara M. Pringsheim, MD, FAAN (Mathison Centre)	The institution of Dr. Pringsheim has received research support from Canadian Institutes of Health Research. The institution of Dr. Pringsheim has received research support from Azrieli Accelerator.
Davide Martino, MD, PhD (Department of Clinical Neurosciences, University of Calgary)	Dr. Martino has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Martino has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Merz Pharma Canada Ltd..

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