The objective of this study is to investigate how fecal microbiota transplant affects plasma inflammatory marker levels in Parkinson's disease patients.

Parkinson's disease has a possible origin in the intestinal nervous system. However, the precise mechanism of how it spreads to the brain has not yet been fully explained. In recent years, gut inflammation in Parkinson disease patients has become a topic of interest. This inflammation may be influenced by the microbiota present in the large intestine. Altering intestinal microbiota with FMT may have a crucial effect on the level of gut inflammation in Parkinson’s disease patients.

The aim of our study is to assess the change of IL-1beta and IL-6, which are markers of inflammation, before and after FMT treatment in Parkinson’s disease patients. Our study includes 20 patients, 13 males and 7 females, with the mean age of 61.9 (+/-7,9). These patients were randomized into either the FMT group or auto-FMT group. The microbiota transplant was performed via colonoscopy. The plasma samples were collected both before and 3 months after FMT treatment. The analysis was performed using the ELISA method. Student’s t-test will be used to compare the outcomes.

The results will determine whether FMT modulates levels of inflammatory markers in plasma of PD patients.