Abstract Details

Title Basal ganglia and brainstem located cerebral microbleeds contribute to gait impairment

Topic Movement Disorders

Presentation(s) P4 - Poster Session 4 (8:00 AM-9:00 AM)

Poster/Presentation
Number 5-016

Objective

To investigate the relationship of quantitative gait parameters with MRI imaging markers in patients of cerebral small vessel disease (CSVD).

Background Gait disorder is one of the most typical symptoms in cerebral small vessel disease (CSVD) patients, while the mechanism behind is still not completely clarified. Previous studies found that white matter hyperintensity (WMH), especially in the frontal lobe, was associated with gait disturbance in CSVD patients. The basal ganglia and brainstem are also frequent sites of small-vessel lesions, such as lacunae and microbleeds. These two parts are also closely related to the regulation of gait and motor function. However, few study has compared that lacune or CMB, small cavitating ischemic infarcts or deposition of hemosiderin, which has a greater impact on gait function.

Design/Methods Clinical data, MRI scanning, and quantitative gait tests were performed on 127 symptomatic CSVD patients. CMBs and lacunar infarcts in regards to anatomical locations and burdens were measured. The correlation between CSVD imaging markers and gait parameters was evaluated using general linear model (GLM) analysis.

Results

Presence of CMBs was significantly associated with speed (β = -0.144, p = 0.0288), stride length (β = -0.088, p = 0.0302), and right step length (β = -0.052, p = 0.0133). Presence of CMBs in basal ganglia was significantly associated with speed, stride length, and step length. Presence of CMBs in brainstem was significantly associated with all the gait parameters including speed, stride length, step length, height, and width. Presence of CMBs in cerebellum was significantly associated with speed. However, having lacunes was not associated with worse gait performances.Basal ganglia and brainstem located CMBs are determinants of impacts of MRI markers on gait impairment in symptomatic CSVD patients.

Conclusions

Basal ganglia and brainstem located CMBs are determinants of impacts of MRI markers on gait impairment in symptomatic CSVD patients.

Authors/Disclosures
Hejiao Mao PRESENTER	Hejiao Mao has nothing to disclose.
Ning Su, MD (Peking Union Medical College Hospital)	Dr. Su has nothing to disclose.
Jiangxia Zhang	No disclosure on file
Wencheng Zhu	No disclosure on file
	No disclosure on file
Xiangmin Fan	No disclosure on file
Fei Han	Fei Han has nothing to disclose.
Jun Ni	Jun Ni has nothing to disclose.
Lixin Zhou	Lixin Zhou has nothing to disclose.
Ming Yao	Ming Yao has nothing to disclose.
Feng Tian	No disclosure on file
Yi-Cheng Zhu, MD, PhD (Peking Union Medical College Hospital)	Dr. Zhu has nothing to disclose.

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