好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Serum Neurofilament Light-chain Concentrations in Essential Tremor: A Case-Control Study
Movement Disorders
P7 - Poster Session 7 (8:00 AM-9:00 AM)
5-003
We sought to investigate the concentrations of neurofilament light chain (NfL) in essential tremor (ET) patients and healthy controls.
Inquiries into the etiology, pathophysiology, and nosology of essential tremor (ET) stand to benefit from the identification of disease biomarkers. Serum neurofilament light chain (NfL) has emerged as a novel signature of conditions in which neuronal injury reflects an outcome of the ongoing disease process.

In this cross-sectional, case-control, observational study, 41 ET patients and 41 healthy controls underwent clinical assessments and measurement of serum NfL concentration using Simoa technology.

Serum NfL was elevated in ET patients (median = 16.6 pg/mL) versus controls (median = 11.3pg/mL) (p <0.001). NfL concentrations remained higher in ET patients than controls after stratification by sex (p = 0.006 and 0.02, for female and male participants, respectively). This difference persisted after accounting for age, sex and Montreal Cognitive Assessment score in a multiple linear regression model (p = 0.00947, Benjamini-Hochberg correction).
In this sample of ET patients and controls, serum NfL concentrations were significantly higher in ET. Studies in additional cohorts of ET cases would be of value in attempting to replicate these results and assessing diagnostic utility.
Authors/Disclosures
Meagen M. Salinas, MD (North Texas VA Health Care System)
PRESENTER 		The institution of Dr. Salinas has received research support from North Texas VA Health Care System New Investigator Award.
Victor H. Salinas (UT Southwestern Medical Center) The institution of an immediate family member of Dr. Salinas has received research support from Veterans Health Administration.
Nora Hernandez No disclosure on file
Elan D. Louis, MD, MS, FAAN (University of Texas Southwestern Medical Center) Dr. Louis has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wolters Kluwer - Merritt's Textbook of Neurology. Dr. Louis has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Legal Firm. The institution of Dr. Louis has received research support from National Institutes of Health. Dr. Louis has received publishing royalties from a publication relating to health care. Dr. Louis has a non-compensated relationship as a Board of Directors with International Essential Tremor Foundation that is relevant to AAN interests or activities. Dr. Louis has a non-compensated relationship as a Medical Advisory Board with HopeNET that is relevant to AAN interests or activities.