Abstract Details

Title Gambling Associated Risk-Taking Decision in Cerebellar Ataxia

Topic Movement Disorders

Presentation(s) P9 - Poster Session 9 (5:30 PM-6:30 PM)

Poster/Presentation
Number 5-001

Objective We used the Iowa Gambling Task (IGT) to assess the decision-making process associated with impulsive and compulsive behaviors in people with cerebellar ataxia (CA).

Background Individuals with CA can develop impulsive and compulsive behaviors that significantly affect their and their family’s quality of life.

Design/Methods Sixty individuals with CA and thirty age-matched controls were enrolled in the study to complete the IGT. No participants had a prior or comorbid neurologic or psychiatric disorder associated with impulsivity. IGT performance in each of the five 20-trial blocks was compared between groups and the progression of participants’ performance was assessed with simple linear regression models. Subgroup analyses were performed with genetic and non-genetic CA cases.

Results CA cases obtained significantly lower IGT total scores than controls (-5.30 ± 37.53 vs. 21.30 ± 37.37, p=0.004). In addition, those with CA made riskier decisions throughout the task compared to controls. Although both CA and controls learned to make decisions with more favorable outcomes over the course of completing the IGT, CA participants never matched the controls’ performance. IGT performance did not correlate with ataxia severity or depressive symptoms.

Conclusions The IGT may capture a unique behavioral symptom of CA and may serve as a screening tool for impulse control disorders in CA. Future studies may help elucidate the mechanisms underlying impaired decision-making in CA and further the understanding of a broader spectrum of cerebellar cognitive affective syndrome.

Authors/Disclosures
Ruo-Yah Lai PRESENTER	Ms. Lai has nothing to disclose.
	No disclosure on file
Christian Amlang, MD (SUNY Downstate)	Dr. Amlang has nothing to disclose.
Chi-Ying (Roy) Lin, MD, FAAN (Baylor College of Medicine)	Dr. Lin has received research support from Texas Alzheimer's Research and Care Consortium (TARCC). Dr. Lin has received research support from CurePSP. Dr. Lin has received research support from Mike Hogg Fund. Dr. Lin has received research support from The Michael J. Fox Foundation Parkinson's Progression Markers Initiative (PPMI). Dr. Lin has a non-compensated relationship as a Secretary with Broadway for Ataxia Foundation (a 501 (c) (3) non-profit organization) that is relevant to AAN interests or activities.
Tiffany Chen	Tiffany Chen has nothing to disclose.
	No disclosure on file
	No disclosure on file
Sheng-Han Kuo, MD, FAAN (Columbia University)	Dr. Kuo has nothing to disclose.

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