To identify differentially regulated microRNAs between patients with and without migraine. 

Migraine is a common neurological disorder with a high burden of disease. For some years, there has been significant interest in searching for biomarkers that can help diagnose, stratify, and discover new therapies. MicroRNAs are proposed as potential diagnostic biomarkers that can support already established clinical criteria.

A systematic search was performed using four databases. Searches were performed using MeSH terms and keywords until August 2021. We included studies that evaluated circulating microRNAs in blood or serum of people with migraine, with no restrictions on age, race, or gender. A narrative synthesis of the findings of the included studies and a summary of deregulated microRNAs in the context of migraine were provided. Functional characterization of microRNAs was performed using DIANA-miRPath v3.0 software, using the KEGG database. In the end, metabolic pathway junctions were searched, and significant up- and down-regulated RNAs were selected.