Abstract Details

Title Validation of Icobrain Aria - An AI-based Software Tool for Automated Detection and Quantification of Amyloid-related Imaging Abnormalities

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) S1 - Alzheimer’s Disease and Related Dementias (1:48 PM-2:00 PM)

Poster/Presentation
Number 005

Objective Evaluate the performance of an automated detection and quantification tool for identification and severity assessment of amyloid-related imaging abnormalities (ARIA).

Background Amyloid beta-directed monoclonal antibody therapies may be associated with ARIA-E(edema/sulcal effusion), and ARIA-H (hemorrhage and superficial siderosis). Studies have shown that clinicians find it challenging to identify or evaluate ARIA. As treatment decisions are informed by ARIA presence and severity, an assistive automated detection and diagnosis tool may help to improve radiological reading.

Design/Methods ARIA-E and ARIA-H were identified on 2D T2 FLAIR and T2*-GRE images, respectively. icobrain aria, an automated detection and diagnosis tool, was trained on data from the EMERGE clinical trial (475 FLAIR, 326 T2*GRE images) using U-net-style convolutional neural networks. Ground truth was established by three expert neuroradiologists. 16 radiologists evaluated ARIA for 199 cases, assisted and unassisted by icobrain aria. Sensitivity and specificity of assisted and unassisted readings relative to ground truth were compared for three categories of ARIA (none, mild, moderate-or-severe).

Results Sensitivity of detection for ARIA-E and ARIA-H increased significantly when reading was assisted by icobrain aria compared to unassisted reads (from 47.2% to 70.2% for mild ARIA-E; from 83.7% to 95.3% for moderate-or-severe ARIA-E; from 60.0% to 71.0% for mild ARIA-H; from 85.5% to 94.4% for moderate-or-severe ARIA-H). In ARIA-free cases, assisted reads had specificity of 83.0% for mild ARIA-E, 80.3% for mild ARIA-H, 94.0% for moderate-or-severe ARIA-E, and 99.4% for moderate-or-severe ARIA-H.

Conclusions By increasing sensitivity of ARIA detection by radiologists, icobrain aria may help improve safety monitoring for patients on amyloid beta-directed monoclonal antibody therapies. Additionally, icobrain aria may help to bridge the gap between expert and non-expert readers.

Authors/Disclosures
Annemie Ribbens PRESENTER	Annemie Ribbens has received personal compensation for serving as an employee of icometrix. Annemie Ribbens has stock in icometrix. Annemie Ribbens has received intellectual property interests from a discovery or technology relating to health care.
Diana Sima	Diana Sima has received personal compensation for serving as an employee of icometrix.
Thanh Vân Phan (icometrix)	No disclosure on file
Simon Van Eyndhoven (icometrix)	Simon Van Eyndhoven has received personal compensation for serving as an employee of icometrix.
Sophie Vercruyssen (Icometrix NV)	No disclosure on file
Ricardo Magalhaes (Icometrix)	Ricardo Magalhaes has received personal compensation for serving as an employee of icometrix.
Celine Maes (icometrix)	No disclosure on file
Rafay Khan (icometrix)	Rafay Khan has received personal compensation for serving as an employee of icometrix.
Joshua Guo	Joshua Guo has received personal compensation for serving as an employee of Biogen. Joshua Guo has stock in Biogen. Joshua Guo has received intellectual property interests from a discovery or technology relating to health care.
Richard W. Hughes, MBBS (Biogen)	Dr. Hughes has received personal compensation for serving as an employee of Biogen. Dr. Hughes has stock in Biogen.
Refaat E. Gabr, PhD	Dr. Gabr has received personal compensation for serving as an employee of Biogen. Dr. Gabr has stock in Biogen.
Paramita Saha-Chaudhuri	No disclosure on file
Gioacchino Curiale, MD	Dr. Curiale has received personal compensation for serving as an employee of Biogen. Dr. Curiale has stock in Biogen.
Shibeshih Belachew, MD	Dr. Belachew has received personal compensation for serving as an employee of Biogen Inc. Dr. Belachew has received stock or an ownership interest from Biogen Inc.
Wim Van Hecke, PhD (University Hospital Brussels)	Dr. Van Hecke has received personal compensation for serving as an employee of icometrix.
Dirk Smeets	Dirk Smeets has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for icometrix. Dirk Smeets has stock in icometrix.

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