好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Herpes Simplex Virus 2 Serology Is Associated with Thinner Whole-brain Cortex in Community-dwelling Older Adults
Aging, Dementia, and Behavioral Neurology
P1 - Poster Session 1 (8:00 AM-9:00 AM)
9-017
The primary purpose of this study was to identify the association between common infectious disease exposures and radiographic features of brain aging in a community-dwelling sample of older adults. 
The contribution of lifetime infectious disease exposures to risk of dementia and brain has re-emerged as an area of interest in recent years. Prior work in the Northern Manhattan Study (NOMAS) identified impaired cognition in cross-sectional analyses and more rapid memory decline in individuals with evidence of prior common infectious disease exposures. 
In this study, we sought to determine the cross-sectional relationship between prior exposure to cytomegalovirus, herpes simplex viruses 1 and 2, Chlamydia pneumoniae, and Helicobacter pylori and three magnetic resonance imaging (MRI) signatures (whole-brain cortical thickness, a previously validated AD signature, and hippocampal volume) in 455 NOMAS participants who were without evidence of dementia at time of enrollment. We performed confounder-adjusted linear regression analyses between neuroimaging scores and both continuous serologies and categorical seropositivity of each pathogen, as well as a combined infectious burden index (IBI). 
We identified that increased serologic titers of herpes simplex virus 2 (HSV-2) were associated with reduced whole-brain cortical thickness across fully-adjusted models, and a combined score of HSV-2 and C. pneumoniae displayed an additive effect on reduced cortical thickness. 

Our findings suggest herpes simplex virus 2 seropositivity may contribute to accelerated brain aging, possibly resulting in an increased vulnerability to cognitive impairment and neurodegenerative disease in aging populations. 
Authors/Disclosures
Jackson A. Roberts, MD
PRESENTER 		Dr. Roberts has nothing to disclose.
Mitchell S. Elkind, MD, MS, FAAN Dr. Elkind has received personal compensation for serving as an employee of American Heart Association. Dr. Elkind has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Atria Academy.
Minghua Liu Minghua Liu has nothing to disclose.
Clinton B. Wright, MD, FAAN (NINDS) An immediate family member of Dr. Wright has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Wright has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Abali Milne Kalil. Dr. Wright has received publishing royalties from a publication relating to health care. An immediate family member of Dr. Wright has received personal compensation in the range of $500-$4,999 for serving as a surveyor with ASTRO.
Tatjana Rundek, MD, PhD The institution of Dr. Rundek has received research support from NIH.
Jose Gutierrez, MD (Columbia University) Dr. Gutierrez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cardiovascular Research Foundation. Dr. Gutierrez has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for White and Rusell. Dr. Gutierrez has received research support from NIH. Dr. Gutierrez has received publishing royalties from a publication relating to health care. Dr. Gutierrez has received publishing royalties from a publication relating to health care.