Safety data for participants ≥55 years were pooled for: people with T2D receiving once-daily oral semaglutide 3, 7 or 14 mg versus comparator (active or placebo) for 26?78 weeks in PIONEER 1?5 and 7?10 (PIONEER pool, N=4186); people with T2D receiving once-weekly subcutaneous semaglutide 0.5 or 1 mg versus comparator (active or placebo) for 30?56 weeks in SUSTAIN 1?5 and SUSTAIN Japan (NCT02207374 and NCT02254291; SUSTAIN pool, N=2825); and people with overweight/obesity (with/without T2D) receiving once-weekly subcutaneous semaglutide 2.4 mg versus placebo for 68?104 weeks in STEP 1–6 (STEP pool, N=1584).

Data from 8595 participants were included. At baseline in the PIONEER, SUSTAIN and STEP pooled datasets, mean (standard deviation [SD]) age was 64.3 (6.4), 63.5 (6.1) and 62.0 (5.6) years, respectively, and mean (SD) body mass index was 30.8 (6.2), 31.0 (6.2) and 35.6 (6.2) kg/m². The percentages of participants with adverse events (AEs) leading to treatment discontinuation in the semaglutide arms of PIONEER, SUSTAIN and STEP were 10.2, 9.1 and 7.7%, respectively, versus 5.2, 3.9 and 3.3% for the comparator arms. Gastrointestinal disorders were the most frequently reported AE system organ class in the semaglutide arm of each pooled dataset. Weight loss was greater with semaglutide versus comparator in all trials, with a tendency to plateau over time.