Abstract Details

Title Association of Triglyceride/High-density Lipoprotein Cholesterol Ratio with the Clinical Prognosis of Ischemic Stroke Patients: A Systematic Review with Meta-analysis

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P2 - Poster Session 2 (11:45 AM-12:45 PM)

Poster/Presentation
Number 5-021

Objective To conduct a systematic review with meta-analysis to synthesize the evidence on the prognostic value of Triglyceride/High-density lipoprotein cholesterol ratio (TG/HDLc) on Ischemic stroke (IS).

Background The ethyology of Ischemic stroke is related to lipid metabolism alterations that result in atherosclerosis build-up. Currently, the TG/HDLc is a non-traditional lipid parameter being studied as a promising predictor of cardiovascular events, including IS, and their clinical outcomes.

Design/Methods A systematic search was conducted in PubMed, Embase, Scopus, Web of Science, and Google Scholar until June 2023. The risk of bias was assessed with the NewCastle-Ottawa tool. A meta-analysis with randomized effects model was applied using the DerSimonian-Laird estimator to calculate the pooled effect of the outcome and a narrative synthesis when this was not possible. GRADE criteria were used to assess the certainty of the evidence.

Results Seven out of 555 articles were selected. Decreased TG/HDLc value was associated with lower mortality rate at 3 months (OR: 0.36; 95%CI: 0.24-0.54; I2=0%) with moderate certainty and lower occurrence of hemorrhagic transformation at one week (OR: 0.59; 95%CI: 0.42-0.81; I2=0%), with low certainty level. With high certainty, increased TG/HDLc was related to a motor sequelae (≥3 modified Rankin scale score) and post-IS cognitive impairment, while the association of this index with severity of IS (National Institutes of Health Stroke Scale score) was assessed with moderate certainty level.

Conclusions

With an analysis of a limited amount of studies, we found with a low level of certainty that TG/HDLc ratio is a useful tool for predicting acute outcomes (hemorraghic transformation and severity); while, with a moderate certainty we reported its utility for late outcomes (motor and cognitive sequelae). However, further prospective studies with community-representative samples of diverse populations are needed.

Authors/Disclosures
Claudia Cruzalegui Bazán PRESENTER	Miss Cruzalegui Bazán has nothing to disclose.
Mario G. Chavez Hermosilla	Mr. Chavez Hermosilla has nothing to disclose.
Patricio Castro Suarez	Mr. Castro Suarez has nothing to disclose.
Juan Duran Pecho	Juan Duran Pecho has nothing to disclose.
Miguel F. Cabanillas Lazo	Mr. Cabanillas Lazo has nothing to disclose.
Carlos Alva-Diaz	Carlos Alva-Diaz has nothing to disclose.

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