Abstract Details

Title Associations Between Atherosclerotic Cardiovascular Disease (ASCVD) Risk Factors and Post-stroke Cognitive Decline

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P2 - Poster Session 2 (11:45 AM-12:45 PM)

Poster/Presentation
Number 5-028

Objective We sought to determine whether atherosclerotic cardiovascular disease (ASCVD) risk factors assessed post-stroke are associated with post-stroke cognitive decline.

Background Eleven ASCVD risk factors, which include high blood pressure and low-density lipoprotein (LDL) cholesterol levels, have been associated with cognitive impairment in stroke-free adults. It is unclear whether such risk factors are associated with similar cognitive implications in individuals who have suffered an ischemic stroke. Post-stroke levels of these risk factors could accelerate future cognitive impairments.

Design/Methods Ischemic stroke patients (n = 31, 10 female, 21 male, mean age = 66.0 years ± 11.0 years, mean days since stroke = 57.7 days ± 28.9 days, 51.6% MCA territory) were administered the MarkVCID neuropsychological battery assessing language, visual perception, memory, and executive function. Raw scores were converted to age, sex, and education adjusted Z scores. ASCVD risk was quantified as a percentage using the American College of Cardiology’s ASCVD Risk Estimator Plus. Pearson r correlations examined the associations between ASCVD scores and cognitive function. Correlations with p ≤ 0.05 were reported.

Results There is a strong negative association between ASCVD scores (mean score = 22.8% ± 15.4%, high risk (≥ 20%) n = 15) and Z scores in all four domains: language (category fluency) (r = -0.36), visual perception (facial recognition) (r = -0.41), memory (Craft Story 21 delayed verbal recall) (r = -0.45), and executive function (Symbol Digit Modalities Test) (r = -0.49).

Conclusions These findings suggest that higher vascular burden as defined by the ASCVD Risk Estimator is correlated with lower cognitive performance in ischemic stroke survivors.

Authors/Disclosures
Thomas Hosseini (Medical College of Wisconsin) PRESENTER	Mr. Hosseini has nothing to disclose.
Chinenye Ibekwe	Miss Ibekwe has nothing to disclose.
Dace Almane	No disclosure on file
Beril Mat	No disclosure on file
Anna G. Przybelski (University of Wisconsin School of Medicine and Public Health)	Miss Przybelski has nothing to disclose.
Jenn Cava (UW Masdison)	No disclosure on file
Joseph Rufflo	No disclosure on file
Troy Showers	No disclosure on file
Shauna Chladek	No disclosure on file
Timothy Choi	No disclosure on file
Ciara Harkin	No disclosure on file
Anusha Adluru	No disclosure on file
Nicole Foytik (UPH-Meriter Hospital)	No disclosure on file
Jana Jones (University of Wisconsin-Madison)	The institution of Jana Jones has received research support from NIH.
Bruce Hermann, PhD (University of Wisconsin School of Medicine and Public Health)	Bruce Hermann, PhD has nothing to disclose.
Vivek Prabhakaran, MD (University of Wisconsin)	Dr. Prabhakaran has nothing to disclose.
Nagesh Adluru	No disclosure on file
Veena A. Nair, PhD (DEPT. OF RADIOLOGY , UW MADISON)	The institution of Dr. Nair has received research support from NIH.

��ɫ��

��ɫ��