Abstract Details

Title Association of the C-reactive Protein/Albumin Ratio with the Prognosis of Aneurysmal Subarachnoid Hemorrhage: A Systematic Review

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P5 - Poster Session 5 (5:30 PM-6:30 PM)

Poster/Presentation
Number 5-009

Objective To summarize the current evidence on the prognostic value of C-reactive protein/Albumin ratio (CAR) on aneurysmal subarachnoid hemorrhage (aSAH).

Background Currently, CAR is a biomarker studied as a promising predictor of severy and poor outcomes in various neurologic events, including aSAH, based on the elevation of the C-reactive protein on cerebral vasospasm and the important role of albumin in modulating immune response on aSAH.

Design/Methods A systematic search was conducted in PubMed, Embase, Scopus, Web of Knowledge, and Google Scholar until April 2023. The risk of bias was assessed with the NewCastle-Ottawa tool. GRADE criteria was used to assess the certainty of the evidence.

Results We selected 3 out of 1408 articles. With moderate certainty, we found a CAR sensitivity and specificity value of 76.6% and 69.5%, respectively, for a modified Rankin Scale score >2 at 3 months. With the same level of certainty, we reported that a higher level of CAR is related to a Glasgow outcome scale score <4 at 3 months (OR: 5.23 95% CI: 1.11-24.59). With moderate certainty, one study showed a mean difference of 0.02 (95% CI: -0.03 a 0.07) between aSAH patients that develop delayed cerebral ischemia (DCI) and those who do not.

Conclusions With moderate evidence, we found that CAR is a useful tool for predicting poor outcomes in aSAH patients. However, we need more studies, especially prospective ones, in order to improve the evidence regarding this index.

Authors/Disclosures
Gerardo M. Luna-Peralta PRESENTER	Mr. Luna-Peralta has nothing to disclose.
Alvaro Lopez	Mr. Lopez has nothing to disclose.
Claudia Cruzalegui Bazán	Miss Cruzalegui Bazán has nothing to disclose.
Miguel F. Cabanillas Lazo	Mr. Cabanillas Lazo has nothing to disclose.

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