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Abstract Details

Association of the C-reactive Protein/Albumin Ratio with the Prognosis of Aneurysmal Subarachnoid Hemorrhage: A Systematic Review
Cerebrovascular Disease and Interventional Neurology
P5 - Poster Session 5 (5:30 PM-6:30 PM)
5-009
To summarize the current evidence on the prognostic value of C-reactive protein/Albumin ratio (CAR) on aneurysmal subarachnoid hemorrhage (aSAH).
Currently, CAR is a biomarker studied as a promising predictor of severy and poor outcomes in various neurologic events, including aSAH, based on the elevation of the C-reactive protein on cerebral vasospasm and the important role of albumin in modulating immune response on aSAH.
A systematic search was conducted in PubMed, Embase, Scopus, Web of Knowledge, and Google Scholar until April 2023. The risk of bias was assessed with the NewCastle-Ottawa tool. GRADE criteria was used to assess the certainty of the evidence.
We selected 3 out of 1408 articles. With moderate certainty, we found a CAR sensitivity and specificity value of 76.6% and 69.5%, respectively, for a modified Rankin Scale score >2 at 3 months. With the same level of certainty, we reported that a higher level of CAR is related to a Glasgow outcome scale score <4 at 3 months (OR: 5.23 95% CI: 1.11-24.59).  With moderate certainty, one study showed a mean difference of 0.02 (95% CI: -0.03 a 0.07) between aSAH patients that develop delayed cerebral ischemia (DCI) and those who do not.
With moderate evidence, we found that CAR is a useful tool for predicting poor outcomes in aSAH patients. However, we need more studies, especially prospective ones, in order to improve the evidence regarding this index.
Authors/Disclosures
Gerardo M. Luna-Peralta
PRESENTER
Mr. Luna-Peralta has nothing to disclose.
Alvaro Lopez Mr. Lopez has nothing to disclose.
Claudia Cruzalegui Bazán Miss Cruzalegui Bazán has nothing to disclose.
Miguel F. Cabanillas Lazo Mr. Cabanillas Lazo has nothing to disclose.