Abstract Details

Title Characterization of Sensory Behaviors in Youth with Chronic Tic Disorder

Topic Child Neurology and Developmental Neurology

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 8-007

Objective To characterize sensory processing in youth with chronic tic disorder (CTD).

Background CTD, a common neurodevelopmental disorder, has a high prevalence of co-occurring neuropsychiatric disorders such as obsessive-compulsive disorder (OCD), attention deficit/hyperactive disorder (ADHD), and anxiety. Sensory processing abnormalities are commonly reported by patients, but the characteristics of abnormal sensory processing are not well described.

Design/Methods We enrolled subjects ages 6 to 17 with CTD. Sensory profiles were determined by the parent-proxy reported Short Sensory Profile 2 (SSP2) or the self-reported Adolescent/Adult Sensory Profile, depending on subject age. Symptom severities for anxiety (Pediatric Anxiety Rating Scale), tics (Yale Global Tic Severity Scale-Total Tic Score (YGTSS-TTS), and premonitory urge severity (Premonitory Urge for Tics Scale (PUTS) were assessed. Anxiety disorder diagnoses were determined using the Anxiety and Related Disorders-IV Child and Parent Interview. OCD and ADHD diagnoses were determined based on DSM-5 criteria. Relationships between abnormal sensory profiles and co-occurring conditions were assessed by Fisher’s exact test. Relationships between urge severity and sensory profile were assessed by chi-square tests. Relationships between tic severity and sensory profile were assessed by ANOVA.

Results Thirty-one subjects completed sensory profiles. Abnormal sensory profiles were reported in registration (n=14, 45%), seeking (n=15, 48%), sensitivity (n=17, 55%), and avoidance (n=16, 52%) categories. Presence of co-occurring OCD was associated with abnormal sensory avoidance (p-value = 0.01). Presence of co-occurring ADHD disorder was associated with abnormal sensory sensitivity (p-value = 0.01). Greater tic severity was associated with abnormal sensory sensitivity (F(2,28) = 4.78, p-value = 0.04). Co-occurring anxiety disorder and urge severity were not significantly associated with abnormal sensory profiles.

Conclusions Youth with CTD, particularly those with co-occurring neuropsychiatric conditions, report abnormal sensory processing in various domains. Tic severity may be related to abnormal sensory sensitivity, which may be a target for management of tic symptoms.

Authors/Disclosures
Erin Hendry PRESENTER	Ms. Hendry has received research support from Child Neurology Foundation.
Nicole Walsh, NP (University of Rochester Medical Center)	Mrs. Walsh has nothing to disclose.
Yelizaveta Sapozhnikov	Miss Sapozhnikov has nothing to disclose.
Jonathan W. Mink, MD, PhD, FAAN	The institution of Dr. Mink has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amicus. The institution of Dr. Mink has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurogene. Dr. Mink has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for TEVA. Dr. Mink has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for PTC Therapeutics. Dr. Mink has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Applied Therapeutics. Dr. Mink has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AAN. The institution of Dr. Mink has received research support from Neurogene. The institution of Dr. Mink has received research support from NIH. Dr. Mink has received publishing royalties from a publication relating to health care. Dr. Mink has received personal compensation in the range of $500-$4,999 for serving as a Member, Study Section with NINDS.
Erika Esposito	No disclosure on file
Leona Oakes (University of Rochester Medical Center)	No disclosure on file
Heather Adams	The institution of Heather Adams has received research support from Current: NIH; Past: Abeona; Batten Research Alliance; American University Centers on Disabilities. An immediate family member of Heather Adams has received publishing royalties from a publication relating to health care. Heather Adams has received personal compensation in the range of $500-$4,999 for serving as a Consultant with Critical Path Institute.
Andrew Ross	No disclosure on file
Jennifer A. Vermilion, MD (University of Rochester)	The institution of Dr. Vermilion has received research support from Centers for Disease Control. The institution of Dr. Vermilion has received research support from Emalex Biosciences. The institution of Dr. Vermilion has received research support from Biomarin. The institution of Dr. Vermilion has received research support from Neurogene, Inc. Dr. Vermilion has received personal compensation in the range of $500-$4,999 for serving as a Invited Speaker with Tourette Association of America. Dr. Vermilion has received personal compensation in the range of $500-$4,999 for serving as a Invited Speaker with Centers for Disease Control and Prevention and American Academy of Pediatrics.

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