Abstract Details

Title Determinants of Health-related Quality of Life of Patients with Focal Epilepsy: A Systematic Literature Review

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) P9 - Poster Session 9 (8:00 AM-9:00 AM)

Poster/Presentation
Number 1-016

Objective This systematic literature review (SLR) queries the existing literature to identify aspects associated with health-related quality of life (HRQoL) in PWFE, with an interest to evaluate modifiable determinants examined using multivariate methods.

Background Focal epilepsy (FE) can be a debilitating condition that negatively impacts a person’s HRQoL. Several studies have been published on HRQoL in people with FE (PWFE) however the determinants of HRQoL have not been comprehensively examined.

Design/Methods The SLR was conducted in accordance with published guidelines.. Articles reporting on the association between HRQoL or employability and a range of demographic, psychosocial, or epilepsy-related factors and medical comorbidities in PWFE were identified. N= 879 abstracts were screened (two independent reviewers), with N=25 studies identified leveraging multivariate methods.

Results Overall, the studies examined a broad range of determinant of HRQoL. These included mood (depression, anxiety), epilepsy-related factors (seizure frequency, number of anti-seizure medications used, adverse event burden, disease duration, age of onset) and cognition. Depression was the most frequently studied determinant, examined in N=14/25 studies and associated with lower HRQoL 86% of the time. Anxiety was another frequently reported determinant, examined in 8 studies and significantly associated with lower HRQoL in 7 of them. Employment was identified as an important consideration for HRQoL, with significance in all studies where it was examined (N=5). Seizure burden was frequently examined (N=14/25 studies). However only when dichotomized into seizure freedom vs experiencing seizures (by Engel class I vs II, III and IV) did it reach significance, notably every time (N=4 studies). When seizure burden was examined as a continuous variable (N=10/25 studies) it was rarely significant (N=1 study). The relationship between depression and HRQoL was overall the strongest among those assessed.

Conclusions Comprehensive understanding of modifiable determinants of HRQoL is relevant to patient health and well-being and can inform everyday clinical care, interventional and observational studies.

Authors/Disclosures
PRESENTER	No disclosure on file
Pamela Engelhart (Biohaven Pharmaceuticals)	No disclosure on file
Jason Lerner, MD (Biohaven)	Dr. Lerner has received personal compensation for serving as an employee of Biohaven Pharmaceuticals. Dr. Lerner has or had stock in Biohaven Pharmaceuticals.
David Dill (Catalyst Pharmaceuticals)	No disclosure on file
Gilbert J. L'Italien	Gilbert J. L'Italien has received personal compensation for serving as an employee of Biohaven Pharmaceuticals. Gilbert J. L'Italien has stock in biohaven pharmaceuticals.
Vladimir Coric	Vladimir Coric has received personal compensation for serving as an employee of Biohaven. Vladimir Coric has received personal compensation in the range of $1,000,000+ for serving as an officer or member of the Board of Directors for Bioahven. Vladimir Coric has stock in Biohaven. Vladimir Coric has received intellectual property interests from a discovery or technology relating to health care.
Joyce H. Matsumoto, MD	Dr. Matsumoto has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Gerson Lehman Group.
Michele Potashman, PhD (Biohaven)	Dr. Potashman has received personal compensation for serving as an employee of Biohaven Pharmaceuticals.

��ɫ��

��ɫ��