好色先生

好色先生

Explore the latest content from across our publications

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

A Case of Parakinesia Brachialis Oscitans and Excessive Yawning from Tumefactive Demyelination
General Neurology
P5 - Poster Session 5 (5:30 PM-6:30 PM)
4-011
To report the phenomenon of parakinesia brachialis oscitans (PBO) in a case of tumefactive demyelination.

PBO is an unusual phenomenon involving transient tonic elevation of a paralyzed arm with yawning. It is usually reported in ischemic stroke with pontomedullary brainstem or internal capsule lesions. While the exact mechanism remains unknown, it is believed to involve the release of subcortically regulated automatisms from cortical inhibition. It is postulated that strong contraction of respiratory muscles during yawning produces proprioceptive signals that spread to the anterior horn cells of C4-C8 and lead to involuntary movement of the affected upper limb. Cortical release may also lead to excessive yawning as seen in patients with multiple sclerosis.

NA
A 31-year-old male with no past medical history presented with five days of progressive left-sided ataxic-hemiparesis which occurred two weeks after an upper respiratory tract infection. He had frequent yawning with associated transient tonic elevation of his paralyzed arm. Neurological exam revealed left hemiplegia. Magnetic resonance imaging revealed a tumefactive lesion involving the deep right subcortical white matter. Lumbar puncture was performed and demonstrated lymphocytic pleocytosis (15 cells/uL) accompanied by oligoclonal banding. Stereotactic biopsy of the lesion revealed focal demyelination without histopathological indications of vasculitis or lymphoproliferation. After treatment with high-dose intravenous corticosteroids and mitoxantrone, he achieved full motor recovery that was sustained throughout the 18-month follow-up period.
Only a few cases of PBO have been documented in the literature, and these instances typically occurred following a stroke. This case uniquely demonstrates the phenomenon of PBO in a patient with a biopsy-confirmed tumefactive demyelinating lesion and excessive yawning.
Authors/Disclosures
Wendy Tsai, MD
PRESENTER
Dr. Tsai has nothing to disclose.
Joshua Lee, MD, PhD Dr. Lee has nothing to disclose.
Tychicus Chen, MD Dr. Chen has nothing to disclose.