Abstract Details

Title Impact of Gut Microbiome and Diet on Post-acute Sequelae of COVID-19 Syndrome (PASC)

Topic Infectious Disease

Presentation(s) P11 - Poster Session 11 (5:30 PM-6:30 PM)

Poster/Presentation
Number 13-007

Objective This review highlights our current understanding of Post-Acute Sequelae of COVID-19 Syndrome (PASC) as it is influenced by gut dysbiosis, nutrition, and diet quality.

Background Long Covid, also known as Post Covid Condition by the CDC or PASC by the NIH, is a syndrome characterized by multi-organ symptoms that exist more than three months post-infection of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). The gastrointestinal (GI) system is a potential avenue for COVID-19’s influence on long-term immunologic modulation as well as a predictor of severity.

Design/Methods A literature search of PubMed was conducted with the following keywords: “Long Covid”, “Post Covid Condition”, or “Postacute Sequelae of SARS_COV-2”, “COVID-19”, “Gut Microbiome” or “Gut Dysbiosis”, “Diet”or “Nutrition” or “Mediterranean Diet” or “MeDi”, “MIND Diet” or “DASH Diet”, “Myalgic encephalomyelitis” or “Chronic fatigue syndrome”, “Post-acute Infection Syndrome”, “Neurodegenerative disease”. Articles included peer-reviewed cohort or cross-sectional studies, meta-analyses, original papers, or systematic reviews predominantly between 2011 and 2023. Articles were excluded if written in non-English language; studied children <18 years old.

Results Recent literature shows that gut dysbiosis is correlated with increased severity and duration of PASC symptoms. Because of the existing association between diet on the components of the gut microbiome, we investigated whether certain nutrients impact the risk of PASC severity. Nutrition, previously shown to play a role in the pathophysiology of neurodegenerative diseases, may feature an avenue to mitigate long-term sequelae of PASC.

Conclusions

We identify a paucity in literature studying the direct effects of nutrition on the development, severity, and symptoms of PASC. Alterations in gut microbiome due to COVID-19 infection and diet may play a role in both PASC susceptibility and length of affliction.

Authors/Disclosures
Zabrina G. Reyes, MD PRESENTER	Ms. Reyes has nothing to disclose.
Mary Catherine Stovall, Medical Student (Tulane University School of Medicine)	Ms. Stovall has nothing to disclose.
Rebecca Solch-Ottaiano (Tulane University)	Rebecca Solch-Ottaiano has nothing to disclose.
Michele Longo, MD, MPH, FAAN	Dr. Longo has received research support from National Institute of Health.

��ɫ��

��ɫ��