Abstract Details

Title Aerobic Fitness Is Associated with Better Cognitive and Motor Function in Mild-moderate Parkinson’s Disease

Topic Movement Disorders

Presentation(s) P4 - Poster Session 4 (11:45 AM-12:45 PM)

Poster/Presentation
Number 3-016

Objective To determine association of aerobic fitness with cognition and motor function in mild-moderate Parkinson’s disease (PD).

Background There is preliminary evidence that aerobic exercise can improve motor and cognitive function in PD.

Design/Methods At baseline of an ongoing clinical trial on aerobic exercise (NCT03808675), independently living PD patients without significant systemic and neurologic comorbidities underwent cognitive and motor (in the “practically defined” OFF and ON states) testing. Aerobic fitness was determined by measuring VO₂max during cycle ergometry.

Results

Fifty-seven PD patients completed baseline testing (Age=66.4±7.5 years; 42 men, 15 women; median Hoehn-Yahr stage II [range I-II], and median MMSE 29 [range 25-30]. Compared to a demographically similar historic control group from our driving studies, the PD group performed mildly but significantly (p<0.05) worse on most cognitive outcome measures, including the MMSE. Within the PD group, VO₂max correlated (Pearson) negatively with age (r=-0.39, p<0.01) and was higher in men than women (23.5±5.3 vs. 20.0±5.1 ml/kg/min, p<0.05). Multiple regression adjusting for age, sex, levodopa equivalent daily dosing (mg; for ON-state motor testing only) revealed that higher VO₂max correlated significantly with better motor performance on the OFF-state Finger Tapping Speed and Peg Board Time (p<0.05), and the ON-state 2-Minute Walk Test distance (p<0.001) and 4-meter Walk Test time (p<0.05). Multiple regression adjusting for age, sex, and education (years) revealed that higher VO₂max correlated significantly with better cognitive performance on the MoCA and Benton Visual Retention Test (p<0.05), and Block Design Test (p=0.05), and on the Flanker Response Inhibition Task (p<0.01). There were no significant correlations with the MDS-UPDRS section scores and memory tests.

Conclusions Aerobic fitness is independently associated with cognition (primarily, executive and visuospatial abilities) and motor function (primarily, OFF-state bradykinesia and dexterity, and ON-state ambulation). Our results suggest that aerobic exercise training may have the potential to improve cognitive and motor functions in PD.

Authors/Disclosures
Ergun Y. Uc, MD (University of Iowa) PRESENTER	An immediate family member of Dr. Uc has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for American Board of Pediatrics. The institution of Dr. Uc has received research support from Department of Veterans Affairs. The institution of Dr. Uc has received research support from Department of Defense. The institution of an immediate family member of Dr. Uc has received research support from NIH. The institution of Dr. Uc has received research support from NIH. The institution of Dr. Uc has received research support from NIH. The institution of Dr. Uc has received research support from Parkinson's Foundation. The institution of Dr. Uc has received research support from NIH.
Alejandro Comellas (University of Iowa)	No disclosure on file
Joel Kline	No disclosure on file
Jeffrey Dawson	Jeffrey Dawson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for iotaMotion. Jeffrey Dawson has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Congress of Neurological Surgeons. The institution of Jeffrey Dawson has received research support from Department of Veterans Affairs. The institution of Jeffrey Dawson has received research support from NIH.
Nandakumar Narayanan, MD, PhD (UIHC)	Dr. Narayanan has nothing to disclose.
Matthew Rizzo, MD, FAAN (University of Nebraska Medical Center)	The institution of Dr. Rizzo has received research support from NIH.
Michelle Voss	No disclosure on file
Steven W. Anderson, PhD	Dr. Anderson has nothing to disclose.
Christina Weber (University of Iowa Hospitals and Clinics)	Christina Weber has nothing to disclose.
Warren Darling	No disclosure on file

��ɫ��

��ɫ��