We included 16 studies reporting 23 patients with SCA. SCA3 was the most common subtype (n 10, 43.5%), followed by SCA2 (n=6, 26.1%). SCA6 and SCA17 each had 2 cases (8.7%), and SCA1, SCA27, and SCA31 each had 1 case (4.4%). The mean age at intervention was 42.1±13.9 years. Dystonia was the primary symptom targeted (n 11, 47.8%), with stimulation sites including bilateral Globus Pallidus internus (Gpi) in 7, unilateral Gpi in 1, ventral oralis posterior thalamic in 1, multi-target bilateral Gpi and subthalamic nucleus (STN) in 1, and bilateral Gpi and dentate nucleus in 1. Tremor was the next most common symptom targeted (9 cases) with Vim thalamus in 7 cases, bilateral STN in 1, and multi-target Vim and STN in 1. Ataxia was targeted in 2 cases with dentate nucleus stimulation. One patient with parkinsonism received bilateral STN stimulation. Outcomes showed dystonia improvement in 6 cases, worsening in 3, and no change in 1. Tremor responded positively in all cases. Ataxia improved in 2 cases while quality of life remained unchanged in 1. Motor scores improved for parkinsonism, but gait deteriorated.