To determine the feasibility and reliability of using precision-mapping techniques for people with Parkinson disease.

We tested the feasibility and reliability of precision-mapping RSFC for people with Parkinson disease. Participants completed multiple fMRI sessions (3-5) up to seven months apart. Using stringent motion censoring, we determined the amount of low-motion, high quality fMRI data per person to establish feasibility. We compared the similarity of RSFC maps across sessions to examine stability and applied split-half analyses to measure the reliability of RSFC maps based on amount fMRI data.

Preliminary analyses reveal the high feasibility and strong reliability of precision-mapping RSFC for people with Parkinson disease. All participants completed multiple fMRI sessions with large amounts of low motion data for each person (>40 min per person, frame retention average = 75%). Individual participant RSFC maps were stable across sessions (r > 0.7) and highly reliable with >40min of data (split-half reliability, r > 0.8).

These results demonstrate the feasibility and reliability of using the precision-mapping technique for identifying individual-level RSFC networks in Parkinson disease.  With this approach, it will now be possible to examine how individual-level variability of RSFC networks relates to variability in clinical manifestations and predicts progression of Parkinson disease.