Cognitive impairment (CI) is recognized as a prevalent and disabling symptom in Multiple Sclerosis (MS), compromising activities of daily living employability, social life and adherence to treatment, sometimes more intensely than physical limitations themselves.The variability of cognitive impairment in the literature was variable and are not describe all the spectrum this disabilities, from mild symptoms to dementia with serious impairment of quality of life

Cognitive Impairment (CC), 60.7% of the total sample presented impairment in more than two cognitive domains, with the remaining 39.3% without cognitive impairment and 23.1% of the sample having 4 or 5 compromised domains. SPMS presented a significantly higher percentage in G3 than in G1 and G2 (50.0% > 4.3% and 9.8% with p < 0.05), demonstrating that patients with the SPMS form are 22 times more likely to be of G3 than those who have the EMRR form..

MS generates the entire variability of the spectrum of cognitive impairment in patients and can increase the possibility of dementia with MS, with specific characteristics and associated with the motor severity.