23 healthy controls (mean age 41.2 (SD 19.1), 65.4% female, 76.9% white, 7.69% Hispanic) and 23 MS patients (mean age 52.1 (SD 12.7), 55.2% female, 86.2% white, 0% Hispanic, mean disease duration 11.9 years (SD 7.00), 58.6% relapsing-remitting MS, mean patient-determined disease steps 3) completed the neuroperformance tests at a single visit. Valid taps per second on FTT using the right and left hands was significantly correlated with manual dexterity test (MDT) performance (Pearson correlation coefficients r = -0.561 and -0.597, respectively). Total number correct on smartphone-administered PST significantly correlated with iPad-administered PST (r = 0.774). Finally, TUG and 5STS times significantly correlated with timed 25-foot walk test (r = 0.954 and 0.825, respectively).

The FTT, PST, TUG, and 5STS, as performed using the smartphone application, demonstrate convergent validity with their analogous MSPT neuroperformance tests. These smartphone-based tests, as an alternative to traditional, in-clinic assessments, may allow for more frequent, remote measurement of MS patients’ level of disability, as well as easy integration of these data into the electronic medical record.