Abstract Details

Title Exploring the Relationship Between Temperament Traits, Psychological Comorbidity, and Functional Disability Assessed with the WHOSAS 2.0 in Persons with Multiple Sclerosis

Topic Multiple Sclerosis

Presentation(s) P6 - Poster Session 6 (8:00 AM-9:00 AM)

Poster/Presentation
Number 6-012

Objective To investigate the association between individual temperament traits, psychological comorbidity, and functional disability assessed with the World Health Organization Disability Assessment Schedule (WHODAS) 2.0, in PwMS.

Background Persons with Multiple Sclerosis (PwMS) often experience psychological comorbidity and functional disability. Understanding the factors contributing to these outcomes is crucial for improving patient care.

Design/Methods We conducted a cross-sectional study in PwMS, assessing their temperament traits, psychological comorbidity, and functional disability. We administered a questionnaire that included demographic characteristics, the Depression Anxiety Stress Scale (DASS-21), and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) short form. Functional disability was assessed with the 36-item version WHODAS 2.0. Statistical analyses, including regression models, were used to explore the relationships between these variables.

Results A total of 111 PwMS completed the study. Our findings revealed several key associations. Patients with higher hyperthymic temperament trait scores exhibited lower total disability scores (beta:-23.1, p=0.0002), suggesting an inverse relationship. Furthermore, stress levels, as measured by the DASS scale, were positively associated with higher total disability scores (betea:1.6; p=0.03). The model explained 40.5% of the variance. Lastly, age was associated with higher disability scores in mobility (beta; 0.5, p=0.01), highlighting the impact of age on mobility-related disability in PwMS.

Conclusions This study sheds light on the complex interplay between individual temperament traits, psychological comorbidity, and functional disability assessed with the WHODAS 2.0 in RRMS patients. Recognizing the importance of hyperthymic traits (overly cheerful, energetic, and enthusiastic), stress, and age as factors influencing disability can aid in tailoring treatment and support strategies. Further research is warranted to delve into the underlying mechanisms and develop targeted interventions to address the unique needs of these patients.

Authors/Disclosures
Carmenrita Infortuna (University of Messina) PRESENTER	Carmenrita Infortuna has nothing to disclose.
Maria Buccafusca	No disclosure on file
ANITA GRACEFFA (University of Messina)	No disclosure on file
Enrica Maiorana	No disclosure on file
Antonio Bruno (University of Messina)	No disclosure on file
Florian P. Thomas, MD, PhD, MA, FAAN (Hackensack Meridian Health)	Dr. Thomas has received personal compensation for serving as an employee of Hackensack Meridian Health. Dr. Thomas has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for MND. Dr. Thomas has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Journal of Spinal Cord Medicine. Dr. Thomas has a non-compensated relationship as a Board Member, Metro New Jersey with National MS Society that is relevant to AAN interests or activities. Dr. Thomas has a non-compensated relationship as a Board Member with American Paraplegia Society that is relevant to AAN interests or activities.
Fortunato Battaglia, MD (Hackensackmeridian School of Medicine)	Dr. Battaglia has nothing to disclose.

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