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Abstract Details

Digital Facial Analysis Correlates with Mood and Cognitive Outcomes with People with MS
Multiple Sclerosis
P6 - Poster Session 6 (8:00 AM-9:00 AM)
6-013
To correlate facial movements as assessed by digital tools with cognition and patient-reported mood in adults with multiple sclerosis (MS).
Facial expressivity is a dimension of emotional expression that has largely not been captured in individuals with MS. Digital facial analysis presents a novel, objective, non-invasive approach to capturing facial movements, which could augment the recognition of subtle indicators of emotional state or cognitive processing.
Adults with MS participating in an ongoing transdiagnostic digital phenotyping study completed: a validated tablet-based cognitive assessment (TabCat) and Hospital Anxiety and Depression Scales (HADS). Videos of their faces were recorded during a spontaneous language task and processed using OpenFace 2.0, an open-access digital tool pre-trained for facial landmark detection and facial action unit (AU) recognition. Instances of AU activation were averaged across frame number. Current analyses explored smiling (“cheek-raiser,” “lip corner-puller”) and eye expression (“brow-furrow,” “blink”) AUs. Correlations between AUs, cognitive testing, and PROs were assessed with univariate regression.
Among participants (n=98, 76% female, 80% relapsing-onset MS), mean age was 47 (SD 12.6), median EDSS 2 (range 0-6.5). HADS-Anxiety scores were ≥8 in 15.6%; HADS-Depression scores were ≥8 in 18.7%. HADS-Anxiety scores correlated with less brow-furrowing (r -0.39, p=0.03) and more smiling (r 0.37, p=0.03); smiling activation was higher in individuals with HADS-Anxiety scores ≥8 (difference 0.36, 95%CI 0.06-0.67, p=0.019). HADS-depression and AUS showed no associations. For the TabCat global cognition measure, Brain Health Assessment Composite (BHA-CS), 37.7% had z-score < -1.5. BHA-CS positively correlated with eye-crinkling (r 0.28, p=0.04) and smiling (r 0.30, p=0.03). The TabCat associative memory test, “Favorites”, positively correlated with eye-crinkling (r 0.30, p=0.03) and smiling (r 0.33, p=0.015).
Digitally identified components of facial expression correlate with metrics of mood and cognition in adults with MS, opening the door for novel modes of data capture in remote evaluation and monitoring.
Authors/Disclosures
Alyssa Nylander, MD, PhD (UCSF)
PRESENTER 		Dr. Nylander has nothing to disclose.
Kyra Henderson (UCSF) Kyra Henderson has nothing to disclose.
Kanishka Koshal No disclosure on file
Nikki Sisodia (University of California San Francisco) Nikki Sisodia has nothing to disclose.
Jaeleene Wijangco Jaeleene Wijangco has nothing to disclose.
Shane Poole (UCSF) Shane Poole has nothing to disclose.
Jim Rowson (131000) No disclosure on file
Cathra Halabi, MD (UCSF Department of Neurology) The institution of Dr. Halabi has received research support from UC Noyce Initiative. The institution of Dr. Halabi has received research support from Weill Institute for Neurosciences Neurohub. The institution of Dr. Halabi has received research support from NIH/NIDCD. The institution of Dr. Halabi has received research support from NIH/StrokeNet. Dr. Halabi has a non-compensated relationship as a Working Group Member with National Academies of Sciences, Engineering, and Medicine Action Collaborative on TBI Care that is relevant to AAN interests or activities. Dr. Halabi has a non-compensated relationship as a Working Group Member with NIH/StrokeNet Recovery and Rehabilitation Working Group that is relevant to AAN interests or activities.
Ethan G. Brown, MD (University of California, San Francisco) Dr. Brown has received personal compensation in the range of $0-$499 for serving as a Consultant for Rune Labs, Inc. An immediate family member of Dr. Brown has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Brown has received personal compensation in the range of $0-$499 for serving as a Consultant for Guidepoint Inc. An immediate family member of Dr. Brown has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Dr. Brown has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NEJM Knowledge Plus. Dr. Brown has stock in 153 Therapeutics. The institution of Dr. Brown has received research support from Michael J. Fox Foundation. The institution of Dr. Brown has received research support from NIH.
Katherine L. Possin, PhD (U of CA San Francisco, Neurology) Dr. Possin has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for ClearView Healthcare Partners. The institution of Dr. Possin has received research support from Quest Diagnostics. The institution of Dr. Possin has received research support from NIH. The institution of Dr. Possin has received research support from The Global Brain Health Institute. The institution of Dr. Possin has received research support from The Rainwater Foundation.
Adam Staffaroni Adam Staffaroni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alector. Adam Staffaroni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Aviado Bio. Adam Staffaroni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CervoMed. Adam Staffaroni has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Prevail Therepeutics/Eli Lilly. Adam Staffaroni has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Takeda. The institution of Adam Staffaroni has received research support from NIH. The institution of Adam Staffaroni has received research support from Bluefield Project To Cure FTD. The institution of Adam Staffaroni has received research support from AFTD/ALSA. Adam Staffaroni has received personal compensation in the range of $500-$4,999 for serving as a Scientific Advisory Board member with AADF.
Riley Bove, MD, FAAN (University of California, San Francisco) Dr. Bove has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion. Dr. Bove has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Amgen. Dr. Bove has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genzyme-Sanofi. Dr. Bove has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for TG Therapeutics. Dr. Bove has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for EMD-Serono. Dr. Bove has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cadenza. The institution of Dr. Bove has received research support from Biogen. The institution of Dr. Bove has received research support from Eli Lilly. The institution of Dr. Bove has received research support from Novartis. The institution of Dr. Bove has received research support from Roche Genentech.