Abstract Details

Title Use of a Trial Innovation Network (TIN) Recruitment Innovation Center (RIC) Survey to Improve Subject Recruitment and Enrollment in an Adolescent Concussion Study: CARE4Kids

Topic Neuro Trauma and Critical Care

Presentation(s) P2 - Poster Session 2 (11:45 AM-12:45 PM)

Poster/Presentation
Number 14-004

Objective To identify barriers and strategies to improve enrollment in multi-site pediatric and adolescent concussion studies.

Background The NINDS-funded CARE4Kids (C4K) Consortium () is currently recruiting the first of two adolescent concussion cohorts (development, validation) to develop a clinical algorithm to predict those who will have prolonged recovery. However, enrollment in pediatric and adolescent concussion studies can be challenging. We hypothesized that utilizing the Recruitment Innovation Center (RIC), part of the Trial Innovation Network (TIN) would help to target actionable challenges to recruitment and enhance subject engagement.

Design/Methods The C4K Consortium Recruitment and Retention Committee partnered with the TIN to develop a survey aimed at identifying roadblocks to subject enrollment and make recommendations. 60 parent/guardian child (ages 11-18yrs) dyads completed a survey through invitations sent to ResearchMatch volunteers. A survey vignette provided respondents with a general idea of C4K trial. 31 dyads ultimately responded, with one child’s responses excluded due to incompleteness.

Results For the first 39 weeks of subject recruitment, the average rate of consent was 1.7 subjects per week, with 1.5 subjects per week completing the first (T1) data collection point. Key findings of the survey included: 1) parents/guardians felt increased compensation would be appropriate for travel costs & time spent at visits, 2) All parents/guardians wanted the study results shared with their child’s doctor. Over the course of 3 months, these results of the TIN RIC survey were implemented after IRB approval. In the second 30 weeks of subject recruitment, the average rate of consent was 3.4 subjects per week, with 2.8 subjects per week completing the T1 data point.

Conclusions Utilization of TIN resources and expertise were instrumental in nearly doubling the consent rate and completion of T1 data point for our development cohort. Early engagement with TIN in pediatric/adolescent studies can improve efficiency in study recruitment.

Authors/Disclosures
Meeryo Choe, MD, FAAN PRESENTER	Dr. Choe has received personal compensation for serving as an employee of Harvard-Westlake School. Dr. Choe has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Legal Cases. The institution of Dr. Choe has received research support from NIH. Dr. Choe has a non-compensated relationship as a Board of Directors with NABIS that is relevant to AAN interests or activities. Dr. Choe has a non-compensated relationship as a Consultant with USA Swimming Concussion Task Force that is relevant to AAN interests or activities.
Kelsee Meyerhoffer (University of Utah)	No disclosure on file
Christopher Miles	No disclosure on file
Lawrence Cook, PhD (University of Utah Data Coordinating Center)	The institution of Dr. Cook has received research support from CDC. The institution of Dr. Cook has received research support from The Guthy-Jackson Charitable Foundation. The institution of Dr. Cook has received research support from Utah Highway Safety Office. The institution of Dr. Cook has received research support from NIH.
Gerard A. Gioia, MD	Dr. Gioia has received personal compensation in the range of $0-$499 for serving as a Consultant for Global Pharma Consultancy. Dr. Gioia has received publishing royalties from a publication relating to health care.
Fred Rivara	No disclosure on file
Christopher Giza, MD, FAAN (UCLA, Depts of Pediatrics and Neurosurgery)	Dr. Giza has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medical Network Speakers Bureau. Dr. Giza has stock in Highmark Interactive. The institution of Dr. Giza has received research support from UCLA: Brain Injury Research Center, Steve Tisch BrainSPORT Program, Easton Clinic for Brain Health. Dr. Giza has received publishing royalties from a publication relating to health care. Dr. Giza has a non-compensated relationship as a Advisory Board with Major League Soccer that is relevant to AAN interests or activities. Dr. Giza has a non-compensated relationship as a Advisory Board with National Basketball Association that is relevant to AAN interests or activities. Dr. Giza has a non-compensated relationship as a Consultant with United States Soccer Federation that is relevant to AAN interests or activities. Dr. Giza has a non-compensated relationship as a Co-founder & Advisor with Symptomwise that is relevant to AAN interests or activities.

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