好色先生

好色先生

Explore the latest content from across our publications
Join The AAN

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Blood Neurofilament Light Chain Measurements in Adults with CNS Histiocytic Neoplasms
Neuro-oncology
P4 - Poster Session 4 (11:45 AM-12:45 PM)
5-012

Evaluate the association between neurofilament light chain (NfL) level in adult patients with histiocytic neoplasms and the presence of CNS involvement.
NfL is an indirect measure of axonal damage, measurable in blood and CSF, and may be useful in screening for neurologic involvement, staging disease, and monitoring treatment response in histiocytic neoplasms.
27 patients with a histiocytic disorder and 39 healthy controls who were seen at Mayo Clinic Rochester and had available stored samples for NfL testing were compared. 

21 patients had Erdheim Chester Disease (ECD), 4 had Langerhans cell histiocytosis (LCH), and 2 had mixed histiocytosis (ECD/ RDD, ECD/ LCH). Median age at onset was 47 years (range 19-82), 12/27 (44%) were female. BRAF V600E mutation was present in 13/23 (57%). Patients with histiocytic neoplasms had significantly higher NfL (48.1 vs 17.7 pg/mL, p<.0001) than healthy controls.  Of patients with histiocytic neoplasms, patients with CNS involvement had higher NfL compared with the patients without CNS disease (63.7 vs 21.1 pg/mL, p=0.002). Those with parenchymal CNS involvement had higher NfL than those without (58.4 vs 28.8 pg/mL, p=0.04). Post gadolinium enhancing lesions on brain or spine MRI were associated with higher NfL levels (69.5 vs 28.8 pg/mL, p=0.003).
Elevated blood NfL is associated with CNS involvement in histiocytic neoplasms, and is associated with active parenchymal disease. Further studies are needed to evaluate whether NfL can be used to screen for CNS involvement and monitor treatment response in patients with histiocytic neoplasms.
Authors/Disclosures
Samantha Banks, MD
PRESENTER 		Dr. Banks has nothing to disclose.
Paul Decker (Mayo Clinic) Paul Decker has nothing to disclose.
Eoin P. Flanagan, MBBCh, FAAN (Mayo Clinic) The institution of Dr. Flanagan has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Flanagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Pharmacy times. The institution of Dr. Flanagan has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for UCB. The institution of Dr. Flanagan has received research support from UCB. The institution of Dr. Flanagan has received research support from Roche. The institution of Dr. Flanagan has received research support from UCB. The institution of Dr. Flanagan has received research support from Merck. The institution of Dr. Flanagan has received research support from Roche. Dr. Flanagan has received publishing royalties from a publication relating to health care. Dr. Flanagan has received publishing royalties from a publication relating to health care. Dr. Flanagan has a non-compensated relationship as a Member of medical Advisory Board with The MOG Project that is relevant to AAN interests or activities. Dr. Flanagan has a non-compensated relationship as a Editorial board member with Journal of The Neurologic Sciences that is relevant to AAN interests or activities. Dr. Flanagan has a non-compensated relationship as a Editorial board member with Neuroimmunology Reports that is relevant to AAN interests or activities. Dr. Flanagan has a non-compensated relationship as a Editorial Board Member with Neurology, Neuroimmunology Neuroinflammation (N2) Journal that is relevant to AAN interests or activities. Dr. Flanagan has a non-compensated relationship as a Editorial Board Member with Neurology that is relevant to AAN interests or activities.
Anastasia Zekeridou, MD, PhD, FAAN (Neuroimmunology Laboratory, Mayo Clinic) The institution of Dr. Zekeridou has received research support from Roche/Genentech. Dr. Zekeridou has received intellectual property interests from a discovery or technology relating to health care. Dr. Zekeridou has received intellectual property interests from a discovery or technology relating to health care. Dr. Zekeridou has received intellectual property interests from a discovery or technology relating to health care. Dr. Zekeridou has received intellectual property interests from a discovery or technology relating to health care.
Ronald Go Ronald Go has nothing to disclose.
Jithma Abeykoon (Mayo Clinic) Jithma Abeykoon has nothing to disclose.
Gaurav Goyal Gaurav Goyal has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Recordati. Gaurav Goyal has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sobi. Gaurav Goyal has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Electra.
Jason Young (Mayo) Jason Young has nothing to disclose.
Matthew Koster The institution of Matthew Koster has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sobi. The institution of Matthew Koster has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Rigel. The institution of Matthew Koster has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amgen. The institution of Matthew Koster has received research support from Sobi.
Robert Vassallo Robert Vassallo has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Regeneron. Robert Vassallo has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Rion. Robert Vassallo has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Robert Vassallo has stock in Rion LLC. The institution of Robert Vassallo has received research support from NIH. The institution of Robert Vassallo has received research support from DOD. Robert Vassallo has received intellectual property interests from a discovery or technology relating to health care.
Jay Ryu (Mayo Clinic) Jay Ryu has nothing to disclose.
Caroline Davidge-Pitts No disclosure on file
Aishwarya Ravindran (Mayo Clinic) Aishwarya Ravindran has nothing to disclose.
Julio Sartori-Valinotti (Mayo Clinic College of Medicine) Julio Sartori-Valinotti has nothing to disclose.
N. Nora Bennani (Mayo Clinic) No disclosure on file
Mithun Shah No disclosure on file
Karen Rech Karen Rech has nothing to disclose.
Corrie Bach No disclosure on file
Jeanette Eckel-Passow The institution of Jeanette Eckel-Passow has received research support from NIH.
W. O. Tobin, PhD, MBBCh, BAO, FAAN (Mayo Clinic) Dr. Tobin has received publishing royalties from a publication relating to health care.