Abstract Details

Title Patients with Neurological or Psychiatric Complications of COVID-19 Have Worse Long-term Functional Outcomes: COVID-CNS- A Multicentre Case-control Study

Topic Infectious Disease

Presentation(s) P1 - Poster Session 1 (12:00 PM-1:00 PM)

Poster/Presentation
Number 078

Objective

Determine the post-discharge functional outcomes of patients hospitalised with COVID-19 neurological or psychiatric complications relative to those with isolated respiratory COVID-19, in terms of activities of daily living (ADLs), employment, and mental health.

Background

Patients hospitalised with COVID-19 often have ongoing morbidity affecting activities of daily living (ADLs), employment, and mental health. However, functional outcomes in patients with COVID-19 neurological or psychiatric complications are poorly understood. We aimed to assess post-discharge functional outcomes of these patients relative to those with isolated respiratory COVID-19.

Design/Methods

We conducted a UK multicentre case-control study of patients hospitalised with COVID-19 (controls) and those with acute neurological or psychiatric complications (cases). Data were collected from clinical records and participants followed-up at 13-16 months for assessment of ADLs, employment, anxiety, and depression.

Results

Between March 2020-July 2022, for 651 patients (362 [56%] cases and 289 [44%] controls), where data were available, a higher proportion of cases than controls had impairment in ADLs (199 [68.9%] vs 101 [51.8%], OR [95%CI] 2.01 [1.40-2.98]) and reported symptoms impacting employment (159 [58.2%] vs 69 [35.6%], OR 2.53 [1.72-3.71]). There was no significant difference in depression or anxiety between overall. For cases, impairment of ADLs was associated with increased risk in females, age >50 years and hypertension (OR 5.43 [1.79-16.96], 3.11 [1.17-8.26], and 3.67 [1.06-12.68]). Those receiving either statins or angiotensin converting enzyme inhibitors had a lower risk (OR 0.09 [0.03-0.37], and 0.17 [0.03-0.84]; AUROC 0.794 [0.71-0.88]).

Conclusions

Patients with neurological or psychiatric complications of COVID-19 had worse functional outcomes than those with respiratory COVID-19 alone in terms of ADLs and employment. Female sex, age >50 years, and hypertension were associated with worse outcomes, and statins or ACE inhibitors with better outcomes.

Authors/Disclosures
Rajish Shil PRESENTER	Mr. Shil has nothing to disclose.

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