Abstract:
This case report details the presentation of a 28-year-old female patient diagnosed with chronic gastrointestinal pseudo-obstruction (CIPO) and concurrent histological evidence of hypoganglionosis on intestinal biopsies. Further diagnostic evaluation demonstrated the presence of anti-Hu antibodies. Despite an extensive diagnostic evaluation, no underlying malignancy was identified. The co-occurrence of Chronic gastrointestinal pseudo-obstruction, hypoganglionosis, and non-paraneoplastic anti-Hu antibody positivity is an infrequently described condition. Management strategies focused on symptom management and supportive care. This case underscores the importance of considering autoimmune aetiologies in the evaluation of CIPO especially in younger patients, and highlights the need for further research into effective therapeutic interventions for this complex condition.