To present the course-changing outcomes of two patients treated with steroid-sparing immunosuppression for Eales Disease with neurological complications.

Eales disease is a rare disease that classically presents with the ophthalmologic triad of retinal peri-phlebitis, recurrent hemorrhages, and neovascularization. Published reports indicate that neurological complications from Eales disease are exceedingly uncommon. Due to its infrequent presentation and uncertain connection with tuberculosis, no standard treatment protocol exists for this condition. Steroid and anti-tuberculous therapy (ATT) is a commonly reported treatment, but results vary. Given the often debilitating disease course, it is imperative to explore novel approaches to improve patient outcomes.

The novel approach used to treat both patients halted their neurological disease progression from Eales disease. When patients present with neurological complications from suspected Eales disease, steroid-sparing immunosuppressants could be a potential line of management.