Abstract Details

Title Temporal and Regional Trends in Burden of Multiple Sclerosis in Pakistan: Insights from the Global Burden of Disease Study 2019

Topic Multiple Sclerosis

Presentation(s) P2 - Poster Session 2 (2:45 PM-3:45 PM)

Poster/Presentation
Number 091

Objective

We aim to identify the temporal trends in the burden of Multiple Sclerosis (MS) in Pakistan from 1990 to 2019, stratified by sex and geographical location.

Background

MS is an autoimmune neurodegenerative condition with high morbidity and mortality but remains understudied in Pakistan – a lower-middle income country with the fifth highest population in the world.

Design/Methods We used data from the Global Burden of Disease Study 2019 to obtain age-adjusted rates for Disability Adjusted Life-Years (DALYs) – years of healthy life lost – per 100,000 individuals due to MS in Pakistan. Annual percentage change (APC) and average APC (AAPC) were calculated using the Joinpoint Regression Program.

Results The DALYs due to MS in Pakistan increased from 8.96 in 1990 to 10.93 in 2019 (AAPC 0.69). Females showed greater DALYs than males both in 1990 (11.02 vs. 7.12) and 2019 (13.06 vs. 8.88) but a less profound AAPC (0.61 vs 0.77). The overall DALYs increased from 1990-2002 and stabilized thereafter. Females exhibited a 1.88% annual increase in DALYs from 1990-1996, followed by a 0.96% annual increase till 2002, a 0.14% annual decline from 2002-2010, and a final 0.21% annual incline till 2019. Males exhibited 1.41% annual increase in DALYs from 1990-1993, a 2.68% annual rise till 1996, and a 1.04% annual rise till 2002; thereafter, the DALYs stabilized till 2012, increased by 0.79% annually from 2012-2015, and stabilized again till 2019. The greatest AAPC in DALYs was observed in Balochistan (0.95), followed by Sindh (0.92), Gilgit-Baltistan (0.84), Azad Jammu & Kashmir (0.80), Islamabad Capital Territory (0.75), Khyber Pakhtunkhwa (0.69), and Punjab (0.61).

Conclusions

We observed a rising burden of MS in Pakistan, with the highest burden among females and Balochistan residents. The increasing burden of MS in Pakistan calls for developing plans suitable for low-resource settings and implementing targeted policies to aid people with MS.

Authors/Disclosures
Mariam Shabih, MD (Marshall Health) PRESENTER	Dr. Shabih has nothing to disclose.
Zain A. Nadeem (Allama Iqbal Medical College)	Mr. Nadeem has nothing to disclose.
Mahad Butt	Mahad Butt has nothing to disclose.
Hamza Ashraf	Hamza Ashraf has nothing to disclose.
Aimen Nadeem	Miss Nadeem has nothing to disclose.
Eeshal Fatima	Mr. Fatima has nothing to disclose.
Haider Ashfaq	Haider Ashfaq has nothing to disclose.
Ahmed Raza	Ahmed Raza has nothing to disclose.
Syed H. Inam, MD	Dr. Inam has nothing to disclose.

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