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Abstract Details

Cryptococcomas in Immunocompetent Patients: A Case Series
Infectious Disease
P1 - Poster Session 1 (12:00 PM-1:00 PM)
085
Present a case series illustrating the challenges in diagnosis and management of cryptococcomas in immunocompetent patients.
Cryptococcomas are solid masses derived from lesions within the body caused by infection by Cryptococcus neoformans, and typically afflicts individuals with compromised immune systems, notably those with HIV or undergoing immunosuppressive therapies post-transplantation. However, it can also manifest in immunocompetent individuals, albeit rarely.
We conducted a retrospective review of cryptococcomas cases at our institution.

We identified a total of four cases involving cryptococcomas in immunocompetent patients.

 Case 1: A 62-year-old male presented with neurological symptoms and an expansive lesion in the brain, diagnosed as cryptococcoma postoperatively. Treatment with amphotericin was initiated, but neurological deficits persisted despite lesion removal.

Case 2: A 62-year-old female with orofacial movements and hemiplegia was diagnosed with a cryptococcoma, but despite treatment, she succumbed to respiratory failure and brain death.

Case 3: A 54-year-old female with a skin lesion developed CNS involvement with multiple lesions, requiring surgical intervention and antifungal therapy. Despite treatment, neurological deficits persisted.

Case 4: A 54-year-old male presented with headache and hemiparesis, diagnosed with a thalamic cryptococcoma. Surgical resection and antifungal therapy were performed, with stable lesion size on follow-up.
Cryptococcomas are not exclusive to immunocompromised patients and should be considered even in immunocompetent individuals during the clinical investigation of solid masses in the brain.
Authors/Disclosures
Anthony Hong, MD
PRESENTER 		Dr. Hong has nothing to disclose.
Savio Batista, MD (Emory University) Mr. Batista has nothing to disclose.
Raphael Camerotte Raphael Camerotte has nothing to disclose.
Igor Costermani No disclosure on file
Abhishek Goyal (HMH JFK University Medical Center) Abhishek Goyal has nothing to disclose.
Plínio G. Lopes No disclosure on file