Abstract Details

Title Strategic Infarct Locations For Stroke-induced Left Ventricular Dysfunction

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S30 - Stroke Risk Factors, Outcomes, and Prevention (4:06 PM-4:18 PM)

Poster/Presentation
Number 004

Objective To identify the neural substrates of post-stroke left ventricular dysfunction (PSLVD) using lesion-symptom mapping.

Background PSLVD, a subtype of stroke-heart syndrome, is associated with poor outcomes in stroke survivors and is considered a consequence of stroke-induced central autonomic network (CAN) disruption. However, the specific CAN component responsible for PSLVD remains elusive.

Design/Methods Patients admitted to our hospital during 2015-2022 with a final diagnosis of ischemic stroke were retrospectively screened. Inclusion criteria: (1) first-ever ischemic stroke confirmed with MRI; (2) echocardiography within three days post-stroke. Exclusion criteria: (1)history of focal brain damage; (2)history of coronary heart disease, heart failure, valvular disease, severe arrhythmia, cardiac surgery, etc. (3)severe systemic conditions e.g. sepsis. Infarcts were manually segmented and spatially normalized. Left ventricular ejection fraction (LVEF) was used to reflect ventricular function. Voxel-based lesion-symptom mapping(VLSM) was performed in FSL Randomise to test the association between lesion location and LVEF while controlling for six covariates (lesion volume, age, sex, history of hypertension, diabetes mellitus, hyperlipidemia). We performed 10-fold cross-validation to test the robustness and generalizability of VLSM results. The intersection between each patient’s lesion and external VLSM map was quantified as “location impact score”. The LVEF residuals (six covariates regressed out) were used to correlate with location impact score.

Results 1,539 eligible patients were included. VLSM found a significant cluster in cerebellar vermis was negatively correlated with LVEF while clusters in anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) were positively correlated with LVEF (TFCE-P_FWE<0.05). Results were highly replicable in cross-validation. Location impact score was significantly correlated with LVEF (Spearman r=0.125, P<10^-6).

Conclusions Lesions involving vermis may increase the risk of ventricular hypofunctioning, while those involving ACC-mPFC may result in ventricular hyperfunctioning. These strategic regions may serve as promising neuromodulation targets to treat ventricular dysfunction caused by stroke or other etiologies.

Authors/Disclosures
Chensheng Pan, MD PRESENTER	Dr. Pan has nothing to disclose.
Yuchao Jia, PhD	Dr. Jia has nothing to disclose.
Zhou Zhu	Dr. Zhu has nothing to disclose.
SUIQIANG ZHU	No disclosure on file

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