Abstract Details Title Prevalence of Anxiety and its Associated Factors in Multiple Sclerosis: Insights from an Algerian Cohort Topic Multiple Sclerosis Presentation(s) P1 - Poster Session 1 (11:45 AM-12:45 PM) Poster/Presentation Number 1-002 Objective To determine the prevalence of anxiety in Algerian patients with Multiple Sclerosis (MS) and investigate its association with psychological, demographic, and disease-related factors, following the 好色先生 (AAN) guidelines for comprehensive neurological care. This study aims to provide insights that will inform multidisciplinary care strategies by identifying predictors of anxiety, such as depression, fatigue, and sexual dysfunction, thereby promoting patient-centered interventions to enhance the quality of life in MS populations. Background Multiple Sclerosis (MS) is a complex disease characterized by a range of symptoms, including motor, sensory, visual, cognitive, sexual, and psychiatric impairments. Among psychiatric manifestations, anxiety and depression frequently occur and significantly affect patients' quality of life. This study aims to determine the prevalence of anxiety in MS patients within an Algerian cohort and examine the associated contributing factors. Design/Methods A cross-sectional study was carried out on 260 MS patients from the Neurology Department at Sidi Bel Abb猫s University Hospital. Inclusion criteria included patients over 18 with a confirmed MS diagnosis based on the 2017 McDonald criteria. Data on demographics, disease type, and duration were collected. Assessments of disability, depression, anxiety, fatigue, cognitive function, and sexual dysfunction were conducted using various validated scales: Expanded Disability Status Scale (EDSS), Hospital Anxiety and Depression Scale (HADS), Fatigue Scale for Motor and Cognitive Functions (FSMCF), Symbol Digit Modalities Test (SDMT), 9-Hole Peg Test (9-HPT), and the 25-Foot Walk Test (25-FWT). Sexual dysfunction was evaluated using the Female Sexual Function Index (FSFI) and the International Index of Erectile Function (IIEF). Statistical analysis was performed with SPSS 20, using Chi- square tests and binary logistic regression to explore correlations, with significance set at p < 0.05. Results Of the 260 participants, 192 were women (73.8%) and 68 were men (26.2%), with a female-to-male ratio of 2.81. The mean age was 38.9 卤 11.1 years, with an average disease duration of 5.83 卤 5.11 years. Anxiety was identified in 38.5% of patients, and 34% exhibited depression based on HADS scores. Fatigue was reported by 77.7% of the cohort. Cognitive dysfunction, as measured by the SDMT, showed a mean score of 42 卤 20. Sexual dysfunction was prevalent, with 55% of women reporting issues, and 76.1% of men experiencing erectile dysfunction. Univariate analysis revealed significant correlations between anxiety, depression, and fatigue (p < 0.001), as well as between anxiety and sexual dysfunction (p < 0.05). However, no significant correlation was found between anxiety and demographic characteristics or motor disability as assessed by EDSS, 9-HPT, or 25-FWT. Multivariate analysis confirmed that psychological factors, including depression and fatigue, were significant predictors of anxiety (p < 0.001). Conclusions This study emphasizes that anxiety in MS patients is predominantly associated with psychological factors such as depression and fatigue rather than the severity of physical disability. The findings underscore the importance of incorporating psychological assessments and addressing sexual dysfunctions as part of a holistic care strategy for improving the quality of life in MS patients. Authors/Disclosures Wail Abdelhamid Amroune, MD PRESENTER Mr. Amroune has nothing to disclose.