RetainYourBrain is an interactive, evidence-based, online software application that identifies users’ risk factors, sets priorities for improvement, educates, provides automated, customized recommendations and support, and longitudinally monitors outcomes. We evaluated its effectiveness on calculated Alzheimer’s risk (Alzheimer’s National University-AD Risk Index [ANU-ADRI]) in a 6-month randomized controlled trial against a time-neutral control in people ≥53 years with a family history of AD (n=987). Analysis of covariance models, with treatment arm as the main factor and baseline risk score as the covariate, were used to evaluate treatment effects on the ANU-ADRI score.

There were no significant differences in baseline characteristics between the intervention and control arms. Participants were largely married/partnered, well-educated, and White (mean age 64.2 years; SD=6.9) and 75% of the sample completed final assessments (n=737 analyzable). This personalized digital health intervention significantly reduced ANU-ADRI total score after 6-months (ß=0.86, 95%CI=[0.02, 1.55], p=0.014) versus controls.