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Abstract Details

Sex-Specific Lesion Network Mapping of Depression Post-Stroke
Cerebrovascular Disease and Interventional Neurology
P7 - Poster Session 7 (5:00 PM-6:00 PM)
14-016

To evaluate whether sex-specific functional connectivity mapping explains observed sex differences in depression post-stroke.

Depression post-stroke is associated with a substantially higher burden of disease, as exemplified by less favorable recovery courses and higher mortality. Female patients are reported to experience depression post-stroke more frequently than male patients. The biological underpinnings of this epidemiological observation are currently not well understood.

We utilized three independent, large single- and multi-center datasets of patients with stroke to investigate associations between sex-specific MRI-based lesion connectivity and established brain circuits of depression (N1=214, derivation cohort; N2=638 and N3=1075, validation cohorts). The functional disconnection elicited by each stroke patient’s lesion was estimated in two ways, based on a female- and male-specific connectome (N=354 each). Sex-specific lesion connectivity effects, both general in nature and specific to previously established connectivity profiles of depression, were evaluated on a whole-brain, voxel-wise basis via Permutation Analysis of Linear Models (PALM).

The evaluation of sex-specific lesion connectivity resulted in broad differences in connectivity strengths: female-specific connectivity was significantly more pronounced, particularly relating to motor cortices (more positive connectivity) and the default mode network (more negative connectivity). In all cohorts, female-specific lesion connectivity was consistently more strongly correlated to connectivity characteristics related to depression than male-specific connectivity (p<0.001).

Female-specific functional lesion connectivity is more closely linked to connectivity characteristics related to depression, potentially indicating a female-specific more innate tendency to develop depressive symptoms after stroke. These results motivate taking biological sex into account when evaluating new therapeutic regimens of post-stroke depression.

 
Authors/Disclosures
Anna K. Bonkhoff, MD (Mass General Brigham)
PRESENTER 		Dr. Bonkhoff has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NeuroImage Clinical (Elsevier).
Frederic Schaper, MD, PhD (Brigham and Women's) Dr. Schaper has nothing to disclose.
Shan Siddiqi, MD (Washington University in St. Louis) Dr. Siddiqi has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Magnus Medical. Dr. Siddiqi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Brainsway Ltd. Dr. Siddiqi has stock in Brainsway Ltd. Dr. Siddiqi has stock in Magnus Medical. Dr. Siddiqi has received intellectual property interests from a discovery or technology relating to health care.
Alexander L. Cohen, MD, PhD, FAAN (Boston Children's Hospital) The institution of Dr. Cohen has received research support from NIH. The institution of Dr. Cohen has received research support from Simons Foundation.
William Drew (Brigham and Women's Hospital) Mr. Drew has nothing to disclose.
Michael Ferguson Michael Ferguson has nothing to disclose.
Christopher Lin No disclosure on file
Anne-Katrin Giese, MD (University Medical Center Hamburg-Eppendorf) Dr. Giese has nothing to disclose.
Robert W. Regenhardt, MD, PhD Dr. Regenhardt has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genomadix. Dr. Regenhardt has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Rapid Medical. Dr. Regenhardt has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Johnson and Bell Trial Lawyers. Dr. Regenhardt has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Buckley, Theroux, Kline, & Cooley Trial Lawyers. The institution of Dr. Regenhardt has received research support from National Institutes of Health. The institution of Dr. Regenhardt has received research support from Society of Vascular and Interventional Neurology. The institution of Dr. Regenhardt has received research support from Heitman Foundation.
Markus D. Schirmer, PhD (Massachusetts General Hospital) The institution of Dr. Schirmer has received research support from National Institute of Aging.
Christina Jern, MD, PhD Prof. Jern has nothing to disclose.
Arne Lindgren, MD, PhD Prof. Lindgren has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Arega. Prof. Lindgren has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurologi i Sverige Journal. Prof. Lindgren has received publishing royalties from a publication relating to health care. Prof. Lindgren has received publishing royalties from a publication relating to health care. Prof. Lindgren has received publishing royalties from a publication relating to health care.
Jane Maguire (University of Technology Sydney) No disclosure on file
Ona Wu (MGH Stroke Research Center) The institution of Ona Wu has received research support from NIH. Ona Wu has received intellectual property interests from a discovery or technology relating to health care. Ona Wu has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH.
Sahar Zafar, MD Dr. Zafar has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer. Dr. Zafar has received research support from NIH. Dr. Zafar has received personal compensation in the range of $5,000-$9,999 for serving as a Speaker for a lecture with Marinus.
John Y. Rhee, MD, MPH (Dana Farber Cancer Institute, Harvard Medical School) Dr. Rhee has stock in NTAP. Dr. Rhee has stock in TSLA. Dr. Rhee has stock in BABA. Dr. Rhee has stock in ZM. Dr. Rhee has stock in GM. Dr. Rhee has stock in PFF. Dr. Rhee has stock in AMZN. Dr. Rhee has stock in META. Dr. Rhee has stock in GE. The institution of Dr. Rhee has received research support from 好色先生. Dr. Rhee has received personal compensation in the range of $0-$499 for serving as a Director of the Hippocratic Forum with Hippocratic Society.
Eyal Y. Kimchi, MD, PhD (Northwestern University) The institution of Dr. Kimchi has received research support from NIH. The institution of an immediate family member of Dr. Kimchi has received research support from NIH.
Andrew M. Naidech, MD, FAAN (Department of Neurology) Dr. Naidech has received publishing royalties from a publication relating to health care.
Amy Brodtmann, MBBS, PhD, FRACP (Monash University) Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NovoNordisk. Prof. Brodtmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medicines Australia. Prof. Brodtmann has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eli Lilly. Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Macpherson Kelley. The institution of Prof. Brodtmann has received research support from National Health and Medical Research Council. The institution of Prof. Brodtmann has received research support from Medical Research Future Fund. The institution of Prof. Brodtmann has received research support from National Heart Foundation. The institution of Prof. Brodtmann has received research support from Victorian Medical Research Acceleration Fund. Prof. Brodtmann has a non-compensated relationship as a Honorary Medical Advisor with Dementia Australia that is relevant to AAN interests or activities. Prof. Brodtmann has a non-compensated relationship as a Brain Health Initiative with Australian Football League that is relevant to AAN interests or activities.
Natalia Egorova (University of Melbourne) No disclosure on file
Sophia Gozzi An immediate family member of Miss Gozzi has stock in LiveHire Ltd.
Thanh Phan, MD (Mayo Clinic) Dr. Phan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer.
Maurizio Corbetta, MD (Department of Neurology, Washington University School of Medicine) Dr. Corbetta has nothing to disclose.
Jordan Grafman, PhD (Cognitive Neuroscience Section) Dr. Grafman has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Grafman has received research support from NIH. Dr. Grafman has received publishing royalties from a publication relating to health care.
Natalia S. Rost, MD, MPH, FAAN, FAHA (Massachusetts General Hospital) Dr. Rost has received personal compensation in the range of $100,000-$499,999 for serving as an officer or member of the Board of Directors for 好色先生. Dr. Rost has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Stroke - AHA/ASA Journal. The institution of Dr. Rost has received research support from NIH. Dr. Rost has received publishing royalties from a publication relating to health care.
Michael D. Fox, MD, PhD (Brigham and Women's Hospital / Harvard Medical School) Dr. Fox has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wiley.