Abstract Details

Title Postural Tachycardia Syndrome (POTS) Symptom Burden: Frequency, Severity, and Impact on Activities of Daily Living

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P1 - Poster Session 1 (11:45 AM-12:45 PM)

Poster/Presentation
Number 7-009

Objective To understand and characterize the most impactful symptoms associated with postural tachycardia syndrome (POTS) and their influence on activities of daily living (ADLs).

Background POTS is a common and often debilitating form of dysautonomia associated with a variety of symptoms, including lightheadedness, multisystemic complaints, and chronic orthostatic intolerance. There is limited available data exploring how the most frequent and severe POTS-related symptoms impact ADLs.

Design/Methods This is a multi-site, baseline cohort study of individuals who met consensus criteria for the diagnosis of POTS based on clinical or laboratory parameters. Participants completed online questionnaires evaluating the frequency and severity of 37 possible POTS-associated symptoms and their impact on ADLs. The most bothersome symptoms were identified based on "every day” frequency and “severe impact” on daily activities. The most severely affected ADLs were determined based on “severe difficulty” responses.

Results Ninety-one participants with clinical or laboratory diagnosis of POTS participated in this study. Mean time since symptom onset was 8.9 years and time since diagnosis was 3.2 years. The five most frequently reported daily symptoms included lightheadedness (57.1%), fatigue (56.0%), temperature dysregulation (53.8%), color/temperature changes in hands/feet (49.5%), and joint pain/instability (46.2%). The five most frequently reported symptoms that led to “severe impact” on daily activities were fatigue (23.3%), weakness (17.6%), worsening symptoms after exertion (17.1%), head/neck pain (17.0%), and fainting (16.0%). The ADLs that were most associated with “severe difficulty” due to POTS-related symptoms were exercise (16.5%), outside recreational activities (14.3%), shopping (13.2%), climbing stairs (12.1%), and travel for pleasure (11.0%).

Conclusions POTS is associated with a significant daily symptom burden, leading to limitations in daily activities. Better understanding these symptoms and their impact will facilitate the development of validated instruments for POTS symptom burden.

Authors/Disclosures
Jonathan Trout, MD PRESENTER	Dr. Trout has nothing to disclose.
Steven Vernino, MD, PhD, FAAN (UT Southwestern Medical Center)	Dr. Vernino has received personal compensation in the range of $500-$4,999 for serving as a Consultant for antag. Dr. Vernino has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CSL Behring. Dr. Vernino has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for argenx. Dr. Vernino has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Kyverna. Dr. Vernino has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Autonomic Neuroscience (Elsevier). The institution of Dr. Vernino has received research support from Takeda. The institution of Dr. Vernino has received research support from NIH/NHLBI. The institution of Dr. Vernino has received research support from Lundbeck. The institution of Dr. Vernino has received research support from Regeneron.
Rachel R. Codden, MPH	Mrs. Codden has nothing to disclose.
Jenavieve Barson	Ms. Barson has nothing to disclose.
Geoffrey Laforge, PhD	An immediate family member of Dr. Laforge has received research support from National Institutes of Health.
Alex Billings	Miss Billings has nothing to disclose.
Melissa M. Cortez, DO (University of Utah Neurology)	The institution of Dr. Cortez has received research support from NIH NINDS. The institution of Dr. Cortez has received research support from Dysautonomia International. Dr. Cortez has received personal compensation in the range of $500-$4,999 for serving as a Content Expert, Reviewer, DSMB with NIH RECOVER project.

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